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Repository for lectin-assisted multimodality data
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MIRAGE
ryanodine receptor 2
Summary
- Gene Symbol
-
- RYR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium channel
- Calmodulin-binding
- Cardiomyopathy
- Coiled coil
- Developmental protein
- Disease variant
- Ligand-gated ion channel
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Sarcoplasmic reticulum
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q92736 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to hypoxia | ||
| regulation of heart rate | ||
| embryonic heart tube morphogenesis | ||
| left ventricular cardiac muscle tissue morphogenesis | ||
| cardiac muscle hypertrophy |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| smooth endoplasmic reticulum | ||
| plasma membrane | ||
| junctional sarcoplasmic reticulum membrane | ||
| membrane | ||
| sarcoplasmic reticulum |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| ryanodine-sensitive calcium-release channel activity | ||
| ryanodine-sensitive calcium-release channel activity | ||
| calcium channel activity | ||
| calcium ion binding | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- E3 ubiquitin-protein ligase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| InterPro |
|---|
| B30.2/SPRY domain superfamily |
| B30.2/SPRY domain |
| Concanavalin A-like lectin/glucanase domain superfamily |
| SPRY domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050431 | arrhythmogenic right ventricular cardiomyopathy | |
| DOID:0060675 | catecholaminergic polymorphic ventricular tachycardia 1 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 6261 | FB:FBgn0011286 | ||
| 6262 | ZFIN:ZDB-GENE-061226-3 | ||
| 6263 | FB:FBgn0011286 | ||
| 20190 | FB:FBgn0011286 | ||
| 20191 | ZFIN:ZDB-GENE-061226-3 | MOUSE11775 | |
| 396856 | PIGXX07478 | ||
| 403615 | CANLF14522 | ||
| 457846 | PANTR24012 | ||
| 689560 | ZFIN:ZDB-GENE-061226-3 | RATNO12911 | |
| 717179 | MACMU21812 |
