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succinate dehydrogenase complex iron sulfur subunit B
Summary
- Gene Symbol
-
- SDHB
- Aliases
-
- iron-sulfur subunit of complex II
- succinate dehydrogenase [ubiquinone] iron-sulfur subunit
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 2Fe-2S
- 3D-structure
- 3Fe-4S
- 4Fe-4S
- Acetylation
- Disease variant
- Electron transport
- Host-virus interaction
- Mitochondrion inner membrane
- Oxidoreductase
- Primary mitochondrial disease
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Proteins
| UniProt | Protein Name |
|---|---|
| P21912 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proton motive force-driven mitochondrial ATP synthesis |
|
|
| aerobic respiration | ||
| mitochondrial electron transport, succinate to ubiquinone |
|
|
| respiratory electron transport chain | ||
| tricarboxylic acid cycle |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| mitochondrial inner membrane | ||
| mitochondrial membrane | ||
| plasma membrane | ||
| mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) | ||
| mitochondrion |
| GO Term | Evidence Code | PMID |
|---|---|---|
| electron transfer activity | ||
| ubiquinone binding | ||
| 2 iron, 2 sulfur cluster binding | ||
| succinate dehydrogenase (ubiquinone) activity | ||
| 4 iron, 4 sulfur cluster binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080533 | Carney-Stratakis syndrome | |
| DOID:0110234 | cataract 4 multiple types | |
| DOID:0110425 | dilated cardiomyopathy 1A | |
| DOID:0111253 | neurofibromatosis 1 | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:10017 | multiple endocrine neoplasia type 1 | |
| DOID:10021 | duodenum cancer | |
| DOID:10154 | small intestine cancer | |
| DOID:10192 | pleomorphic lipoma | |
| DOID:1040 | chronic lymphocytic leukemia |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0002373 | Febrile seizure (within the age range of 3 months to 6 years) |
| HP:0002376 | Developmental regression |
| HP:0002415 | Leukodystrophy |
| HP:0002421 | Poor head control |
| HP:0002474 | Expressive language delay |
| HP:0002505 | Loss of ambulation |
| HP:0002516 | Increased intracranial pressure |
| HP:0002527 | Falls |
| HP:0002574 | Episodic abdominal pain |
| HP:0002640 | Hypertension associated with pheochromocytoma |
| Disease ID | Disease Name |
|---|---|
| ORPHA:276621 |
|
| OMIM:115310 |
|
| OMIM:606864 |
|
| ORPHA:201 |
|
| ORPHA:3208 |
|
| ORPHA:97286 |
|
| OMIM:606764 |
|
| ORPHA:44890 |
|
| ORPHA:29072 |
|
| OMIM:619224 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000586
- Gene Name
- succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 174482 | WB:WBGene00006433 | ||
| 32887 | FB:FBgn0030975 | ||
| 35590 | FB:FBgn0014028 | ||
| 100181830 | CIOIN08963 | ||
| 103187447 | CALMI36772 | ||
| 102358325 | LATCH13447 | ||
| 135352526 | LATCH13447 | ||
| 562149 | ZFIN:ZDB-GENE-030131-8005 | DANRE23737 | |
| 100528601 | ICTPU15933 | ||
| 113582781 | ELEEL30391 |
