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succinate dehydrogenase complex iron sulfur subunit B
Summary
- Gene Symbol
-
- SDHB
- Aliases
-
- iron-sulfur subunit of complex II
- succinate dehydrogenase [ubiquinone] iron-sulfur subunit
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 2Fe-2S
- 3D-structure
- 3Fe-4S
- 4Fe-4S
- Acetylation
- Disease variant
- Electron transport
- Host-virus interaction
- Mitochondrion inner membrane
- Oxidoreductase
- Primary mitochondrial disease
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Proteins
| UniProt | Protein Name |
|---|---|
| P21912 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proton motive force-driven mitochondrial ATP synthesis |
|
|
| aerobic respiration | ||
| mitochondrial electron transport, succinate to ubiquinone |
|
|
| respiratory electron transport chain | ||
| tricarboxylic acid cycle |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| mitochondrial inner membrane | ||
| mitochondrial membrane | ||
| plasma membrane | ||
| mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) | ||
| mitochondrion |
| GO Term | Evidence Code | PMID |
|---|---|---|
| electron transfer activity | ||
| ubiquinone binding | ||
| 2 iron, 2 sulfur cluster binding | ||
| succinate dehydrogenase (ubiquinone) activity | ||
| 4 iron, 4 sulfur cluster binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11054 | urinary bladder cancer | |
| DOID:1107 | esophageal carcinoma | |
| DOID:11105 | fundus albipunctatus | |
| DOID:1115 | sarcoma | |
| DOID:1138 | spinal meningioma | |
| DOID:11459 | pseudotumor cerebri | |
| DOID:11514 | fissured tongue | |
| DOID:11561 | hypertensive retinopathy | |
| DOID:11603 | infant gynecomastia | |
| DOID:117 | heart cancer |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0007400 | Irregular hyperpigmentation |
| HP:0007565 | Multiple cafe-au-lait spots |
| HP:0007663 | Reduced visual acuity |
| HP:0008069 | Neoplasm of the skin |
| HP:0008314 | Decreased activity of mitochondrial complex II |
| HP:0008629 | Pulsatile tinnitus |
| HP:0008675 | Enlarged polycystic ovaries |
| HP:0008872 | Feeding difficulties in infancy |
| HP:0008936 | Axial hypotonia |
| HP:0009711 | Retinal capillary hemangioma |
| Disease ID | Disease Name |
|---|---|
| ORPHA:276621 |
|
| OMIM:115310 |
|
| OMIM:606864 |
|
| ORPHA:201 |
|
| ORPHA:3208 |
|
| ORPHA:97286 |
|
| OMIM:606764 |
|
| ORPHA:44890 |
|
| ORPHA:29072 |
|
| OMIM:619224 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000586
- Gene Name
- succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101171309 | ORYLA20126 | ||
| 100705239 | ORENI39078 | ||
| 100712084 | ORENI56771 | ||
| 102293590 | HAPBU15940 | ||
| 113013876 | ASTCA21198 | ||
| 115583027 | SPAAU39080 | ||
| 115585165 | SPAAU51785 | ||
| 379939 | Xenbase:XB-GENE-970197 | ||
| 108696840 | Xenbase:XB-GENE-17339717 | ||
| 100144957 | Xenbase:XB-GENE-970193 |
