succinate dehydrogenase complex iron sulfur subunit B

Summary
Gene Symbol
  • SDHB
Aliases
  • iron-sulfur subunit of complex II
  • succinate dehydrogenase [ubiquinone] iron-sulfur subunit
Organism
Homo sapiens (human)
External Links
NCBI Gene
6390
HGNC
10681
KEGG Gene ID
hsa:6390
PubChem
6390
Alliance of Genome Resources
Annotation
Keyword
  • 2Fe-2S
  • 3D-structure
  • 3Fe-4S
  • 4Fe-4S
  • Acetylation
  • Disease variant
  • Electron transport
  • Host-virus interaction
  • Mitochondrion inner membrane
  • Oxidoreductase
  • Primary mitochondrial disease
  • Reference proteome
  • Transit peptide
  • Tricarboxylic acid cycle
Proteins
Displaying 1 entry
UniProt Protein Name
P21912
  • Iron-sulfur subunit of complex II
  • Malate dehydrogenase [quinone] iron-sulfur subunit
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
Human Protein Atlas
ENSG00000117118

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K00235
Name
succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
References
Disease
Disease Ontology
Displaying entries 41 - 50 of 230 in total
DO ID Disease Name Source
DOID:11054 urinary bladder cancer
DOID:1107 esophageal carcinoma
DOID:11105 fundus albipunctatus
DOID:1115 sarcoma
DOID:1138 spinal meningioma
DOID:11459 pseudotumor cerebri
DOID:11514 fissured tongue
DOID:11561 hypertensive retinopathy
DOID:11603 infant gynecomastia
DOID:117 heart cancer
The Human Phenotype Ontology
Displaying entries 81 - 90 of 193 in total
HPO ID HPO Term
HP:0002018 Nausea
HP:0002019 Constipation
HP:0002027 Abdominal pain
HP:0002123 Generalized myoclonic seizure
HP:0002151 Increased circulating lactate concentration
HP:0002239 Gastrointestinal hemorrhage
HP:0002313 Spastic paraparesis
HP:0002331 Recurrent paroxysmal headache
HP:0002333 Motor deterioration
HP:0002359 Frequent falls
Displaying all 10 entries
Disease ID Disease Name
ORPHA:276621
  • sporadic pheochromocytoma/secreting paraganglioma
OMIM:115310
  • paragangliomas 4
OMIM:606864
  • Carney-Stratakis syndrome
ORPHA:201
  • Cowden disease
ORPHA:3208
  • mitochondrial complex II deficiency, nuclear type 1
ORPHA:97286
  • Carney-Stratakis syndrome
OMIM:606764
  • gastrointestinal stromal tumor
ORPHA:44890
  • gastrointestinal stromal tumor
ORPHA:29072
  • hereditary pheochromocytoma-paraganglioma
OMIM:619224
  • mitochondrial complex 2 deficiency, nuclear type 4
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000586
Gene Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024