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solute carrier family 22 member 4

Summary

Gene Symbol

Slc22a4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64037

PubChem

64037

Alliance of Genome Resources

RGD:621149

Annotation

Keyword

ATP-binding
Cell membrane
Glycoprotein
Mitochondrion
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HEF8
Q9R141	Organic cation/carnitine transporter 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	IEA ISO
sodium ion transport	IEA
amino acid import across plasma membrane	IEA ISO
quaternary ammonium group transport	IBA IDA IMP ISO	10825452 17616214
acetate ester transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane

carnitine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane

carnitine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

organic substance transport [inference]

organic cation transport [inference]

carnitine transport

carnitine transmembrane transport

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

carnitine transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

carnitine transmembrane transport

acetate ester transport

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

carnitine transmembrane transport

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

carnitine transmembrane transport

import into cell [inference]

amino acid import across plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrial membrane	IEA ISO ISS
apical plasma membrane	IEA ISO ISS
mitochondrion	ISO
basal plasma membrane	IEA ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

mitochondrial membrane

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
symporter activity	IEA
quaternary ammonium group transmembrane transporter activity	IBA IDA IMP ISO	10825452 17616214
amino-acid betaine transmembrane transporter activity	IEA ISO ISS
carnitine transmembrane transporter activity	IEA ISO
amino acid transmembrane transporter activity	IEA ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

neurotransmitter transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

organic cation transmembrane transporter activity

quaternary ammonium group transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

modified amino acid transmembrane transporter activity [inference]

acetate ester transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

salt transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

solute carrier family 22 member 4

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
carnitine transport
monoatomic ion transport
nitrogen compound transport
nucleotide binding
organic cation transmembrane transporter activity

Displaying **all 5** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like
Organic cation transport protein/SVOP
Sugar transporter, conserved site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 98 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6583		HGNC:10968	HUMAN80660
Mus musculus	30805	10090_1:003a88	MGI:1353479	MOUSE05370
Drosophila melanogaster	38664		FB:FBgn0035647
Drosophila melanogaster	41791		FB:FBgn0038262
Caenorhabditis elegans	172841		WB:WBGene00003842
Caenorhabditis elegans	174130		WB:WBGene00015088
Caenorhabditis elegans	177649		WB:WBGene00003837
Danio rerio	393822		ZFIN:ZDB-GENE-040426-1517
Bos taurus	508155			BOVIN33019
Macaca mulatta	710179			MACMU38114