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solute carrier family 22 member 4

Summary

Gene Symbol

Slc22a4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64037

PubChem

64037

Alliance of Genome Resources

RGD:621149

Annotation

Keyword

ATP-binding
Cell membrane
Glycoprotein
Mitochondrion
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HEF8
Q9R141	Organic cation/carnitine transporter 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
sulfur amino acid transport	IDA	18670092
triglyceride metabolic process	ISO
triglyceride metabolic process	IEA
sodium ion transport	IEA
neurotransmitter transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular nitrogen compound metabolic process [inference]

amino-acid betaine metabolic process [inference]

carnitine metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane

carnitine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration [inference]

liver regeneration

animal organ development [inference]

animal organ regeneration [inference]

liver regeneration

gland development [inference]

liver development [inference]

liver regeneration

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organic cyclic compound [inference]

response to vitamin D

response to dsRNA [inference]

response to exogenous dsRNA

response to lipid [inference]

response to nitrogen compound [inference]

response to dsRNA [inference]

response to exogenous dsRNA

response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

secretion [inference]

body fluid secretion [inference]

lactation

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane

carnitine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

organic substance transport [inference]

organic cation transport [inference]

acetylcholine transport [inference]

acetylcholine uptake

carnitine transport

carnitine transmembrane transport

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

carnitine transmembrane transport

acetylcholine transport [inference]

acetylcholine uptake

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

sulfur amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

sulfur amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

carnitine transmembrane transport

acetate ester transport

acetylcholine transport [inference]

acetylcholine uptake

nitrogen compound transport [inference]

amino acid transport [inference]

sulfur amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

carnitine transmembrane transport

acetylcholine transport [inference]

acetylcholine uptake

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

carnitine transmembrane transport

sulfur compound transport [inference]

sulfur amino acid transport

import into cell [inference]

amino acid import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

lactation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrion	IDA	34252480
basal plasma membrane	ISS
basal plasma membrane	ISO
basal plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

mitochondrial membrane

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
acetylcholine transmembrane transporter activity	ISS
acetylcholine transmembrane transporter activity	ISO
acetylcholine transmembrane transporter activity	IEA
ATP binding	IEA
organic cation transmembrane transporter activity	IDA	10825452

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

neurotransmitter transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

organic cation transmembrane transporter activity

quaternary ammonium group transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

modified amino acid transmembrane transporter activity [inference]

acetate ester transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

salt transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Solute carrier family 22 member 22

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like

Ortholog

Displaying entries **1 - 10** of **110** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	6580	SGD:S000000695
Saccharomyces cerevisiae S288C	6581	SGD:S000000695
Saccharomyces cerevisiae S288C	6582	SGD:S000000695
Homo sapiens	6583	Xenbase:XB-GENE-484416	HUMAN80660
Xenopus tropicalis	6584	Xenbase:XB-GENE-484416
Saccharomyces cerevisiae S288C	9356	SGD:S000000695
Saccharomyces cerevisiae S288C	9376	SGD:S000000695
Caenorhabditis elegans	9389	WB:WBGene00015088
Saccharomyces cerevisiae S288C	9390	SGD:S000000695
Saccharomyces cerevisiae S288C	10864	SGD:S000000695