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Guidelines

MIRAGE

semaphorin 3F

Summary

Gene Symbol

SEMA3F

Organism

Homo sapiens (human)

External Links

NCBI Gene

6405

PubChem

6405

Alliance of Genome Resources

HGNC:10728

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
C9JPG5
Q13275	Sema III/F Semaphorin IV
Q59G50

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **21 - 21** of 21 in total

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GO Term	Evidence Code	PMID
neural crest cell migration involved in autonomic nervous system development	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

sympathetic neuron projection extension

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

trunk neural crest cell migration [inference]

ventral trunk neural crest cell migration

neural crest cell migration involved in autonomic nervous system development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

motor neuron axon guidance [inference]

branchiomotor neuron axon guidance

sympathetic neuron projection guidance

developmental process [inference]

anatomical structure arrangement [inference]

cranial nerve structural organization [inference]

anatomical structure development [inference]

tissue development [inference]

ganglion development [inference]

sympathetic ganglion development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

sympathetic neuron projection extension

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

sympathetic neuron projection extension

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

sympathetic neuron projection extension

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of synapse organization [inference]

regulation of postsynapse organization

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	TAS	8786119
plasma membrane	IBA
glutamatergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
semaphorin receptor binding	IBA
neuropilin binding	IBA
chemorepellent activity	IDA	15814794
chemorepellent activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

semaphorin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
chemorepellent activity
negative regulation of axon extension involved in axon guidance
neural crest cell migration
positive regulation of cell migration
semaphorin receptor binding
semaphorin-plexin signaling pathway

Displaying **all 4** entries
InterPro
Sema domain superfamily
Sema domain
Semaphorin
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **131 - 133** of **133** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Tursiops truncatus	117313937		TURTR08393
Scophthalmus maximus	118308875		SCOMX27359
Panthera leo	122214372		PANLE23254

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Last updated: April 7, 2025