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colony stimulating factor 1 receptor, a

Summary

Gene Symbol

csf1ra

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

64274

PubChem

64274

Alliance of Genome Resources

ZFIN:ZDB-GENE-001205-1

Annotation

Keyword

ATP-binding
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Inflammatory response
Innate immunity
Magnesium
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3DHL0
Q9I8N6	CSF-1 receptor Proto-oncogene c-Fms homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 37 in total

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase signaling pathway	IBA
transmembrane receptor protein tyrosine kinase signaling pathway	IEA
positive regulation of cell population proliferation	IBA
positive regulation of macrophage chemotaxis	IMP	22497888
microglia differentiation	IMP	22493295

GO Hierarchy

biological process

immune system process

immune response [inference]

organ or tissue specific immune response [inference]

immune response in brain or nervous system

innate immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

macrophage chemotaxis

myeloid leukocyte migration [inference]

macrophage migration [inference]

macrophage chemotaxis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

primary metabolic process [inference]

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

cytokine-mediated signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation [inference]

microglia differentiation

osteoclast differentiation

glial cell differentiation [inference]

microglia differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation [inference]

microglia differentiation

osteoclast differentiation

pigment cell differentiation [inference]

cell development [inference]

glial cell development [inference]

microglia development

hemopoiesis [inference]

myeloid cell development [inference]

bone cell development [inference]

osteoclast development

cell maturation [inference]

osteoclast maturation

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

melanocyte migration

leukocyte migration [inference]

leukocyte chemotaxis [inference]

macrophage chemotaxis

myeloid leukocyte migration [inference]

macrophage migration [inference]

macrophage chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

macrophage chemotaxis

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

swimming behavior

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

osteoclast maturation

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

microglia development

hemopoiesis [inference]

myeloid cell development [inference]

bone cell development [inference]

osteoclast development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation [inference]

microglia differentiation

osteoclast differentiation

glial cell differentiation [inference]

microglia differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation [inference]

microglia differentiation

osteoclast differentiation

pigment cell differentiation [inference]

cell development [inference]

glial cell development [inference]

microglia development

hemopoiesis [inference]

myeloid cell development [inference]

bone cell development [inference]

osteoclast development

cell maturation [inference]

osteoclast maturation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

macrophage chemotaxis

pigmentation

developmental pigmentation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

organ or tissue specific immune response [inference]

immune response in brain or nervous system

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of hemopoiesis [inference]

regulation of osteoclast development

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of developmental process [inference]

positive regulation of retina development in camera-type eye [inference]

positive regulation of neural retina development

positive regulation of multicellular organismal process [inference]

positive regulation of retina development in camera-type eye [inference]

positive regulation of neural retina development

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of odontogenesis

regulation of cell differentiation [inference]

regulation of pigment cell differentiation [inference]

regulation of xanthophore differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of osteoclast development

positive regulation of developmental process [inference]

positive regulation of retina development in camera-type eye [inference]

positive regulation of neural retina development

regulation of neural retina development [inference]

positive regulation of neural retina development

regulation of retina development in camera-type eye [inference]

positive regulation of retina development in camera-type eye [inference]

positive regulation of neural retina development

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination

regulation of hemopoiesis [inference]

regulation of osteoclast development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of myelination

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of pigment cell differentiation [inference]

regulation of xanthophore differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of osteoclast development

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of cellular component organization [inference]

regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of retina development in camera-type eye [inference]

positive regulation of neural retina development

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination

regulation of hemopoiesis [inference]

regulation of osteoclast development

regulation of pigmentation [inference]

regulation of developmental pigmentation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
plasma membrane	IEA
membrane	IEA
receptor complex	IBA
CSF1-CSF1R complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
protein kinase activity	IEA
protein tyrosine kinase activity	IEA
transmembrane receptor protein tyrosine kinase activity	IEA
GPI-linked ephrin receptor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

collagen receptor activity [inference]

protein tyrosine kinase collagen receptor activity

neurotrophin receptor activity [inference]

brain-derived neurotrophic factor receptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Macrophage colony-stimulating factor 1 receptor 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
growth factor binding
metal ion binding
nucleotide binding
positive regulation of cell migration
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying entries **11 - 14** of 14 in total

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InterPro
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, active site
Tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, receptor class III, conserved site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070343	CSF1R-related brain malformation and osteopetrosis	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **107** in total

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Species	Gene ID	Orthologous MAtrix
Aotus nancymaae	105715381	AOTNA00121
Propithecus coquereli	105821583	PROCO11586
Microcebus murinus	105858431	MICMU14545
Dipodomys ordii	105992611	DIPOR13992
Salmo salar	106611874	SALSA144489
Equus asinus asinus	106838490	EQUAS13699
Sinocyclocheilus grahami	107568129	SINGR91594
Sinocyclocheilus grahami	107588320	SINGR19346
Rhinopithecus bieti	108532049	RHIBE02222
Cyprinus carpio carpio	109046024	CYPCA84061

GlyTouCan

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LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements