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Guidelines

MIRAGE

SIL1 nucleotide exchange factor

Summary

Gene Symbol

SIL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

64374

PubChem

64374

Alliance of Genome Resources

HGNC:24624

JoGo

SIL1

TogoVar

SIL1

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein folding	NAS	11101517
cotranslational protein targeting to membrane	ISS
intracellular protein transport	NAS	11101517

GO Hierarchy

biological process

cellular process [inference]

protein folding

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	HDA	16502470
endoplasmic reticulum	NAS	11101517
endoplasmic reticulum	IDA	12356756
endoplasmic reticulum	IBA
endoplasmic reticulum lumen	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
adenyl-nucleotide exchange factor activity	IDA	12356756
adenyl-nucleotide exchange factor activity	IBA
protein binding	IPI	12356756 24473200 25416956 28514442 31258504 32296183 33961781
identical protein binding	IPI	31258504
unfolded protein binding	NAS	11101517

GO Hierarchy

molecular function

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl-nucleotide exchange factor activity

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl-nucleotide exchange factor activity

molecular function regulator activity [inference]

ATPase regulator activity [inference]

adenyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nucleotide exchange factor sil1

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Armadillo-like helical
Armadillo-type fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9277	primary cerebellar degeneration	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026