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gremlin 2, DAN family BMP antagonist

Summary

Gene Symbol

GREM2

Organism

Homo sapiens (human)

External Links

NCBI Gene

64388

PubChem

64388

Alliance of Genome Resources

HGNC:17655

Annotation

Keyword

Cytokine
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Heparin-binding
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H772	Cysteine knot superfamily 1, BMP antagonist 2 DAN domain family member 3 Protein related to DAN and cerberus

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
animal organ morphogenesis
embryonic body morphogenesis	ISS
cytokine-mediated signaling pathway	ISS
sequestering of BMP from receptor via BMP binding	IBA
determination of dorsal identity	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation [inference]

determination of dorsal identity

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

body morphogenesis [inference]

embryonic body morphogenesis

embryonic morphogenesis [inference]

embryonic body morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of cytokine activity

regulation of binding [inference]

regulation of protein binding [inference]

regulation of receptor binding [inference]

regulation of cytokine activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytokine activity	IEA
heparin binding	ISS
BMP binding	IBA
identical protein binding	IEA
receptor ligand activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity

cytokine activity

cytokine binding [inference]

BMP binding

identical protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gremlin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
BMP binding
animal organ morphogenesis
sequestering of BMP from receptor via BMP binding

Displaying **all 3** entries
InterPro
Cystine knot, C-terminal
Cystine-knot cytokine
DAN

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050591	tooth agenesis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	23892	WB:WBGene00009389
Mus musculus	23893	ZFIN:ZDB-GENE-131127-498	MOUSE30734
Caenorhabditis elegans	26585	WB:WBGene00009389
Caenorhabditis elegans	50566	WB:WBGene00009389
Danio rerio	64388	ZFIN:ZDB-GENE-030911-9
Rattus norvegicus	289264		RATNO06949
Pan troglodytes	469727		PANTR24021
Canis lupus familiaris	490367		CANLF17301
Danio rerio	550399		DANRE04437
Macaca mulatta	708280		MACMU21584