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ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

Summary

Gene Symbol

ARAP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

64411

PubChem

64411

Alliance of Genome Resources

HGNC:24097

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Cytoskeleton
GTPase activation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9H7C1
Q8WWN8	Centaurin-delta-3
Q05CH1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoskeleton organization	TAS	15569923
signal transduction	IEA
vesicle-mediated transport	TAS	15569923
regulation of actin cytoskeleton organization	IBA
positive regulation of GTPase activity

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ruffle	IEA
cytoplasm	IBA
cytoskeleton	IEA
plasma membrane	IEA
lamellipodium	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	ISS
protein binding	IPI	15090612 31980649
phosphatidylinositol-3,4,5-trisphosphate binding	IDA	11804589
phosphatidylinositol-3,4,5-trisphosphate binding	IBA
zinc ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

ion binding [inference]

anion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
phosphatidylinositol-3,4,5-trisphosphate binding

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InterPro
ARAP, RhoGAP domain
ARFGAP/RecO-like zinc finger
Arf GTPase activating protein
ArfGAP domain superfamily
PH-like domain superfamily
Pleckstrin homology domain
Ras-associating domain
Rho GTPase activation protein
Rho GTPase-activating protein domain
Sterile alpha motif domain

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	64411	Xenbase:XB-GENE-983598
Mus musculus	106952		MOUSE24009
Drosophila melanogaster	116984	FB:FBgn0030808
Drosophila melanogaster	116985	FB:FBgn0030808
Rattus norvegicus	361314		RATNO13773
Pan troglodytes	462149		PANTR36414
Canis lupus familiaris	487188		CANLF06661
Danio rerio	558931		DANRE06978
Macaca mulatta	701400		MACMU38191
Monodelphis domestica	100027875		MONDO07191