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DNA cross-link repair 1C

Summary

Gene Symbol

DCLRE1C

Organism

Homo sapiens (human)

External Links

NCBI Gene

64421

PubChem

64421

Alliance of Genome Resources

HGNC:17642

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
DNA recombination
DNA repair
Disease variant
Endonuclease
Exonuclease
Magnesium
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
SCID

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8V8TLX1	DNA cross-link repair 1C protein
B3KMX5	DNA cross-link repair 1C protein
Q96SD1	DNA cross-link repair 1C protein Protein A-SCID SNM1 homolog C SNM1-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
telomere maintenance	IBA
adaptive immune response	IEA
double-strand break repair via nonhomologous end joining	TAS
double-strand break repair via nonhomologous end joining	IBA
response to ionizing radiation	IEA

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

immune response [inference]

adaptive immune response

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

immune response [inference]

adaptive immune response

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

interstrand cross-link repair

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleoplasm	IDA
Golgi apparatus	IDA
nonhomologous end joining complex	IDA	25941166

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

nonhomologous end joining complex

catalytic complex [inference]

DNA repair complex [inference]

nonhomologous end joining complex

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
single-stranded DNA endodeoxyribonuclease activity	IDA	11955432
damaged DNA binding	IBA
endonuclease activity	TAS
protein binding	IPI	22529269 23219551 23523427 25941166 28780862 33961781
5'-3' exonuclease activity	IDA	11955432

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

DNA endonuclease activity [inference]

single-stranded DNA endodeoxyribonuclease activity

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

5'-3' DNA exonuclease activity

5'-3' exonuclease activity

5'-3' DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

5'-3' DNA exonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

single-stranded DNA endodeoxyribonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

5'-3' DNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

single-stranded DNA endodeoxyribonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

5'-3' DNA exonuclease activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA cross-link repair

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
5'-3' DNA exonuclease activity
damaged DNA binding
double-strand break repair via nonhomologous end joining
interstrand cross-link repair

Displaying **all 2** entries
InterPro
DNA repair metallo-beta-lactamase
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060010	Omenn syndrome	Alliance of Genome Resources
DOID:0090012	severe combined immunodeficiency with sensitivity to ionizing radiation	Alliance of Genome Resources
DOID:12177	common variable immunodeficiency	Alliance of Genome Resources
DOID:627	severe combined immunodeficiency	Alliance of Genome Resources

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	64421	Xenbase:XB-GENE-952753
Pongo abelii	100173437		PONAB00779
Callithrix jacchus	100402124		CALJA39713
Saimiri boliviensis boliviensis	101039809		SAIBB17740
Gorilla gorilla gorilla	101129710		GORGO00286
Aotus nancymaae	105719778		AOTNA29401