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MBL associated serine protease 2

Summary

Gene Symbol

Masp2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64459

PubChem

64459

Alliance of Genome Resources

RGD:620214

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Complement pathway
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Hydroxylation
Innate immunity
Lectin
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q9JJS8	MBL-associated serine protease 2 Mannose-binding protein-associated serine protease 2
A2VCV7
A0A0G2K392
F7FHD3
A6IU76

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
complement activation, lectin pathway	ISO
complement activation, lectin pathway	IBA
complement activation, lectin pathway	IEA
proteolysis	IEA
complement activation	NAS	10586086

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response

complement activation, lectin pathway

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, lectin pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

complement activation, lectin pathway

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response

complement activation, lectin pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, lectin pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, lectin pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
complement component C4b binding	ISO
complement component C4b binding	IEA
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IDA	15060079
serine-type endopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

opsonin binding [inference]

complement component C4b binding

complement binding [inference]

complement component C4b binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mannan-binding lectin serine

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
calcium ion binding
complement activation, classical pathway
complement activation
hydrolase activity
immune system process
metal ion binding
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

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InterPro
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Peptidase S1A, complement C1r/C1S/mannan-binding
Serine proteases, trypsin domain
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10747	Xenbase:XB-GENE-1007491	HUMAN47440
Mus musculus	17175	Xenbase:XB-GENE-1007491	MOUSE39731
Xenopus tropicalis	64459	Xenbase:XB-GENE-1007491
Canis lupus familiaris	487447		CANLF07183
Bos taurus	505819		BOVIN08299
Danio rerio	560277		DANRE24161
Macaca mulatta	722714		MACMU23096
Equus caballus	100056770		HORSE28453
Callithrix jacchus	100408774		CALJA42135
Pongo abelii	100458242		PONAB17612

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements