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inducible T-cell co-stimulator

Summary

Gene Symbol

Icos

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64545

PubChem

64545

Alliance of Genome Resources

RGD:620123

Annotation

Keyword

Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9R1T7	Activation-inducible lymphocyte immunomediatory molecule
A6IPD8	Activation-inducible lymphocyte immunomediatory molecule
A6IPD9	Activation-inducible lymphocyte immunomediatory molecule

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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Last »
GO Term	Evidence Code	PMID
T cell tolerance induction	IMP	16220623
T cell tolerance induction	IBA
T cell costimulation	IDA	11006126
T cell costimulation	IBA
T cell costimulation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

tolerance induction [inference]

T cell tolerance induction

lymphocyte costimulation [inference]

T cell costimulation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

cell adhesion [inference]

cell-cell adhesion

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell activation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

alpha-beta T cell differentiation [inference]

alpha-beta T cell differentiation involved in immune response [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

CD4-positive, alpha-beta T cell differentiation [inference]

CD4-positive, alpha-beta T cell differentiation involved in immune response [inference]

T-helper cell differentiation [inference]

T follicular helper cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IEA
external side of plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
signaling receptor activity	ISO
signaling receptor activity	IEA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

inducible T-cell costimulator

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
T cell costimulation
T cell tolerance induction

Displaying **all 3** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin-like fold
Inducible T-cell costimulator

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:820	myocarditis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements