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solute carrier family 7 member 2

Summary

Gene Symbol

Slc7a2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64554

PubChem

64554

Alliance of Genome Resources

RGD:68387

Annotation

Keyword

Alternative splicing
Amino-acid transport
Cell membrane
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
B5D5N9	Low affinity cationic amino acid transporter 2 Solute carrier family 7 member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
L-arginine transmembrane transport	IDA ISO	11329533 16998217 8626679
regulation of macrophage activation	ISO
establishment of localization in cell	ISO
L-amino acid transport	ISO
macrophage activation	ISO

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

reactive nitrogen species metabolic process [inference]

nitric oxide metabolic process [inference]

nitric oxide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

production of molecular mediator involved in inflammatory response [inference]

nitric oxide production involved in inflammatory response

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-lysine transmembrane transport

L-alpha-amino acid transmembrane transport

ornithine transport [inference]

L-ornithine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-lysine transmembrane transport

L-alpha-amino acid transmembrane transport

ornithine transport [inference]

L-ornithine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

modified amino acid transport [inference]

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-lysine transmembrane transport

L-alpha-amino acid transmembrane transport

ornithine transport [inference]

L-ornithine transmembrane transport

modified amino acid transport [inference]

import into cell [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte activation [inference]

regulation of macrophage activation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of macrophage activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of macrophage activation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cell junction	IEA ISO
membrane	ISO
plasma membrane	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
L-arginine transmembrane transporter activity	IBA IDA ISO TAS	11329533 12371970 16998217 8626679
L-lysine transmembrane transporter activity	IBA
amino acid transmembrane transporter activity	ISO
L-amino acid transmembrane transporter activity	ISO
L-ornithine transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

basic amino acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

basic amino acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

salt transmembrane transporter activity [inference]

L-lysine transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cationic amino acid transporter 2

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
L-ornithine transmembrane transporter activity

Displaying **all 2** entries
InterPro
Amino acid/polyamine transporter I
Cationic amino acid transporter, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111666	proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **118** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	850489	SGD:S000001839
Saccharomyces cerevisiae S288C	852803	SGD:S000003045
Monodelphis domestica	100021629		MONDO25613
Sus scrofa	100037298		PIGXX11096
Ornithorhynchus anatinus	100078044		ORNAN04245
Taeniopygia guttata	100227076		TAEGU23516
Callithrix jacchus	100397322		CALJA08836
Pongo abelii	100433164		PONAB34858
Ailuropoda melanoleuca	100472779		AILME08122
Xenopus tropicalis	100485546	Xenbase:XB-GENE-994549