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VPS16 core subunit of CORVET and HOPS complexes

Summary

Gene Symbol

VPS16

Organism

Homo sapiens (human)

External Links

NCBI Gene

64601

PubChem

64601

Alliance of Genome Resources

HGNC:14584

Annotation

Keyword

3D-structure
Alternative splicing
Autophagy
Cytoplasmic vesicle
Disease variant
Dystonia
Endosome
Lysosome
Membrane
Nitration
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H269

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
vacuole fusion, non-autophagic	IBA
endosome to lysosome transport	IMP	25783203
endosomal transport	IBA
intracellular protein transport	IEA
endosomal vesicle fusion	NAS	24554770 31092635

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

vacuole fusion [inference]

vacuole fusion, non-autophagic

vesicle organization [inference]

vesicle fusion [inference]

endosomal vesicle fusion

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

endosomal vesicle fusion

vacuole fusion [inference]

vacuole fusion, non-autophagic

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

endosomal vesicle fusion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosomal transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosomal transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
endosome	IBA
CORVET complex	NAS	31092635
late endosome membrane	IEA
lysosome	IDA	11382755 21802320
endosome membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

HOPS complex

vesicle tethering complex [inference]

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11382755 20190753 23901104 24554770 25266290 25783203 26496610 28013294 29778605 33422265 33961781 35271311
actin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Vacuolar protein

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
actin binding

Displaying **all 4** entries
InterPro
Vacuolar protein sorting-associated protein 16
Vps16, C-terminal domain superfamily
Vps16, C-terminal
Vps16, N-terminal

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060937	dystonia 30	Alliance of Genome Resources
DOID:3211	lysosomal storage disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	41107	FB:FBgn0285911
Mus musculus	80743	MGI:2136772	MOUSE34295
Caenorhabditis elegans	175913	WB:WBGene00006516
Rattus norvegicus	296159	RGD:1359414	RATNO26316
Xenopus tropicalis	448414	Xenbase:XB-GENE-5856292
Bos taurus	505361		BOVIN04775
Danio rerio	798985	ZFIN:ZDB-GENE-050809-9	DANRE38890
Saccharomyces cerevisiae S288C	856062	SGD:S000005966
Monodelphis domestica	100026493		MONDO26342
Equus caballus	100052817		HORSE21318

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements