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VPS16 core subunit of CORVET and HOPS complexes

Summary

Gene Symbol

VPS16

Organism

Homo sapiens (human)

External Links

NCBI Gene

64601

PubChem

64601

Alliance of Genome Resources

HGNC:14584

Annotation

Keyword

3D-structure
Alternative splicing
Autophagy
Cytoplasmic vesicle
Disease variant
Dystonia
Endosome
Lysosome
Membrane
Nitration
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H269

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
vacuole fusion, non-autophagic	IBA
endosome to lysosome transport	IMP	25783203
endosomal transport	IBA
intracellular protein transport	IEA
endosomal vesicle fusion	NAS	24554770 31092635

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

vacuole fusion [inference]

vacuole fusion, non-autophagic

vesicle organization [inference]

vesicle fusion [inference]

endosomal vesicle fusion

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

endosomal vesicle fusion

vacuole fusion [inference]

vacuole fusion, non-autophagic

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

endosomal vesicle fusion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosomal transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosomal transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

endosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
recycling endosome	IDA	19109425
early endosome	IDA	19109425
late endosome	IDA	11382755 19109425
HOPS complex	IBA IDA NAS	19109425 23901104 24554770 25783203
clathrin-coated vesicle	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

HOPS complex

vesicle tethering complex [inference]

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11382755 20190753 23901104 24554770 25266290 25783203 26496610 28013294 29778605 33422265 33961781 35271311
actin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Vacuolar protein

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
actin binding

Displaying **all 4** entries
InterPro
Vacuolar protein sorting-associated protein 16
Vps16, C-terminal domain superfamily
Vps16, C-terminal
Vps16, N-terminal

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060937	dystonia 30	Alliance of Genome Resources
DOID:3211	lysosomal storage disease	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 78** of 78 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Strigops habroptila	115610585		STRHB18431
Corvus moneduloides	116444431		CORMO22357
Chelonoidis abingdonii	116829265		CHEAB22568
Rhinolophus ferrumequinum	117015832		RHIFE23747
Balaenoptera musculus	118881122		BALMU20634
Panthera leo	122215748		PANLE01747
Ursus americanus	123799065		URSAM07926
Pongo pygmaeus	129021364	9600_0:004de8

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements