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sphingosine-1-phosphate receptor 1

Summary

Gene Symbol

s1pr1

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

64617

PubChem

64617

Alliance of Genome Resources

ZFIN:ZDB-GENE-001228-2

Annotation

Keyword

Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q1LV63	Sphingosine 1-phosphate receptor Edg-1
Q9DDK4	Sphingosine 1-phosphate receptor Edg-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
angiogenesis	IBA
vasculature development	IMP	23229546
vasculature development	IGI	23229546
sprouting angiogenesis	IMP	22951644
sphingosine-1-phosphate receptor signaling pathway	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

sprouting angiogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

system development [inference]

vasculature development

locomotion [inference]

taxis [inference]

chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

regulation of blood vessel remodeling

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

regulation of blood vessel remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	ISS
plasma membrane	IBA
plasma membrane	IEA
membrane	IC

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
sphingosine-1-phosphate receptor activity	ISS
sphingosine-1-phosphate receptor activity	IBA
sphingosine-1-phosphate receptor activity	IEA
lysophosphatidic acid receptor activity	IDA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

bioactive lipid receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sphingosine 1-phosphate receptor 1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
sphingosine-1-phosphate receptor activity

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Sphingosine 1-phosphate receptor

Ortholog

Displaying entries **81 - 87** of 87 in total

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Species	Gene ID	Orthologous MAtrix
Strigops habroptila	115611938	STRHB10975
Corvus moneduloides	116448406	CORMO26369
Chelonoidis abingdonii	116834776	CHEAB15184
Rhinolophus ferrumequinum	117015178	RHIFE25731
Balaenoptera musculus	118881811	BALMU23464
Panthera leo	122228164	PANLE11010
Ursus americanus	123795148	URSAM10281