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MIRAGE
heparan sulfate-glucosamine 3-sulfotransferase 6

Summary
Gene Symbol
  • HS3ST6
Organism
Homo sapiens (human)
NCBI Gene
64711
GGDB ID
HGNC
14178
map
  • 16p13.3
OMIM
KEGG Gene ID
hsa:64711
PubChem
64711
Alliance of Genome Resources
Annotation
Keyword
  • Disulfide bond
  • Glycoprotein
  • Golgi apparatus
  • Reference proteome
  • Signal-anchor
  • Transferase
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q96QI5
  • Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 2 entries
GO Term Evidence Code PMID
blastocyst hatching
heparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
heparan sulfate glucosamine 3-O-sulfotransferase
Functional Category
  • G: Carbohydrate transport and metabolism
  • M: Cell wall/membrane/envelope biogenesis
  • O: Posttranslational modification, protein turnover, chaperones
Displaying all 3 entries
Gene Ontology
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
sulfotransferase activity
transferase activity
Displaying all 3 entries
InterPro
Heparan sulfate sulfotransferase
P-loop containing nucleoside triphosphate hydrolase
Sulfotransferase domain
GlycoGene Database (GGDB)
GGDB ID
gg237
Gene Symbol
  • HS3ST6
KEGG BRITE Database
Orthology
K09679
Name
[heparan sulfate]-glucosamine 3-sulfotransferase 6 [EC:2.8.2.-]
References
Rhea

RHEA:15461

3'-phosphoadenylyl sulfate
H+ + adenosine 3',5'-bisphosphate
Enzyme
PMID
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:14735 hereditary angioedema
The Human Phenotype Ontology
Displaying all 8 entries
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000282 Facial edema
HP:0002014 Diarrhea
HP:0002027 Abdominal pain
HP:0002572 Episodic vomiting
HP:0007514 Edema of the dorsum of hands
HP:0012027 Laryngeal edema
HP:0100665 Angioedema
Displaying 1 entry
Disease ID Disease Name
OMIM:619367
  • angioedema, hereditary, 8
PubChem Disease
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
Ortholog
Displaying entries 31 - 40 of 70 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
100705727 ORENI70637
100730401 CAVPO02956
100953994 OTOGA11182
101020207 PAPAN16650
101064528 TAKRU24132
101083991 FELCA35809
101600108 JACJA03167
102191480 CAPHI16516
102366195 LATCH08486
102434441 MYOLU13151
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025