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Standards Ontologies Notations
ST6 beta-galactoside alpha-2,6-sialyltransferase 1

Summary
Gene Symbol
  • ST6GAL1
Aliases
  • CDw75
  • ST6Gal I
Organism
Homo sapiens (human)
External Links
NCBI Gene
6480
GGDB ID
HGNC
10860
mRNA
map
  • 3q27-q28
Protein
OMIM
KEGG Gene ID
hsa:6480
PubChem
6480
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Phosphoprotein
  • Reference proteome
  • Secreted
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
P15907
  • B-cell antigen CD75
  • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
  • ST6Gal I
  • Sialyltransferase 1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entry 11 - 11 of 11 in total
GO Term Evidence Code PMID
regulation of substrate adhesion-dependent cell spreading
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
Human Protein Atlas
ENSG00000073849

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas
GlycoGene Database (GGDB)
GGDB ID
gg054
Gene Symbol
  • ST6GAL1
Reactions
Displaying all 2 entries
Donor Acceptor Product Reference
CMP-Neu5Ac
G58896AZ
CMP-Neu5Ac
G00055MO
Displaying all 4 entries
Donor Acceptor Product Reference
CMP-Neu5Ac
G00055MO
CMP-Neu5Ac
G58896AZ
CMP-Neu5Ac
G00049MO
CMP-Neu5Ac
G84224TW
G28868ZC
Displaying all 10 entries
Donor Acceptor Product Reference
CMP-Neu5Ac
G00031MO
CMP-Neu5Ac
G00049MO
CMP-Neu5Ac
G00056MO
CMP-Neu5Ac
G84224TW
CMP-Neu5Ac
G91237TK
CMP-Neu5Ac
G49108TO
CMP-Neu5Ac
G65889KE
CMP-Neu5Ac
G48558GR
CMP-Neu5Ac
G57321FI
CMP-Neu5Ac
G21856LC
Orthologous Gene
Displaying all 2 entries
Species Protein mRNA
Rattus norvegicus NP_671738 NM_147205
Mus musculus NP_666045 NM_145933
KEGG BRITE Database
Orthology
K00778
Name
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.3.1]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05990
Rhea

RHEA:21552

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate
H+ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP
Enzyme
PMID

RHEA:11836

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate
H+ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP
Enzyme
PMID

RHEA:52104

a β-D-galactoside + CMP-N-acetyl-β-neuraminate
an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H+ + CMP
Enzyme
PMID
Disease
Disease Ontology
Displaying entries 41 - 50 of 107 in total
DO ID Disease Name Source
DOID:1793 pancreatic cancer
DOID:1837 diabetic ketoacidosis
DOID:1936 atherosclerosis
DOID:219 colon cancer
DOID:2237 hepatitis
DOID:234 colon adenocarcinoma
DOID:2348 arteriosclerotic cardiovascular disease
DOID:2349 arteriosclerosis
DOID:235 colonic benign neoplasm
DOID:2394 ovarian cancer
Ortholog
Displaying entry 81 - 81 of 81 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
108318502 CEBIM24809
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024