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MIRAGE

cytochrome P450 family 3 subfamily A member 43

Summary

Gene Symbol

CYP3A43

Organism

Homo sapiens (human)

External Links

NCBI Gene

64816

PubChem

64816

Alliance of Genome Resources

HGNC:17450

Annotation

Keyword

Alternative splicing
Heme
Membrane
Microsome
Monooxygenase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9HB55

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
steroid metabolic process	IBA
oxidative demethylation	IBA
cytochrome metabolic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

protein metabolic process [inference]

cytochrome metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	ISS
monooxygenase activity	TAS
iron ion binding	IEA
heme binding	IEA
testosterone 6-beta-hydroxylase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

steroid hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

estrogen 16-alpha-hydroxylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome p450

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	1551	ZFIN:ZDB-GENE-060929-96
Xenopus tropicalis	1576	Xenbase:XB-GENE-984218
Xenopus tropicalis	1577	Xenbase:XB-GENE-984218
Drosophila melanogaster	6916	FB:FBgn0039519
Xenopus tropicalis	64816	Xenbase:XB-GENE-984218
Pan troglodytes	472456		PANTR40891
Meleagris gallopavo	678669		MELGA04398
Macaca mulatta	709770		MACMU32359
Monodelphis domestica	100010745		MONDO30917
Monodelphis domestica	100010783		MONDO30262

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025