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MIRAGE
SIX homeobox 1
Summary
- Gene Symbol
-
- SIX1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Activator
- Apoptosis
- Cytoplasm
- DNA-binding
- Developmental protein
- Disease variant
- Homeobox
- Non-syndromic deafness
- Nucleus
- Phosphoprotein
- Reference proteome
- Repressor
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q15475 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| ureteric bud development | ||
| branching involved in ureteric bud morphogenesis | ||
| organ induction | ||
| kidney development |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
GO Hierarchy
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Homeobox protein
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| Homeobox domain |
| Homeobox protein SIX1, N-terminal SD domain |
| Homeobox-like domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110553 | autosomal dominant nonsyndromic deafness 23 | |
| DOID:14702 | branchiootorenal syndrome | |
| DOID:2154 | nephroblastoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 6495 | Xenbase:XB-GENE-480717 | ||
| 20471 | MOUSE08959 | ||
| 114634 | RATNO36471 | ||
| 452952 | PANTR08890 | ||
| 490719 | CANLF17969 | ||
| 511371 | BOVIN01514 | ||
| 703696 | MACMU41408 | ||
| 100027093 | MONDO01800 | ||
| 100060564 | HORSE23421 | ||
| 100156847 | PIGXX15260 |
