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Guidelines

MIRAGE

mitochondrial ribosomal protein L44

Summary

Gene Symbol

MRPL44

Organism

Homo sapiens (human)

External Links

NCBI Gene

65080

PubChem

65080

Alliance of Genome Resources

HGNC:16650

Annotation

Keyword

3D-structure
Disease variant
Endonuclease
Mitochondrion
Primary mitochondrial disease
RNA-binding
Reference proteome
Ribosomal protein
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H9J2	39S ribosomal protein L44, mitochondrial

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
RNA processing	IEA
mitochondrial translation	NAS	27023846
mitochondrial translational elongation	IMP	23315540
mitochondrial translational elongation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

translational elongation [inference]

mitochondrial translational elongation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

translational elongation [inference]

mitochondrial translational elongation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

translational elongation [inference]

mitochondrial translational elongation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

protein metabolic process [inference]

translation [inference]

mitochondrial translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

translational elongation [inference]

mitochondrial translational elongation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

translational elongation [inference]

mitochondrial translational elongation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

translational elongation [inference]

mitochondrial translational elongation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	IDA
mitochondrion	IDA	28892042
mitochondrion	HTP	34800366
mitochondrial inner membrane	NAS	27023846

GO Hierarchy

cellular component

protein-containing complex [inference]

mitochondrial protein-containing complex [inference]

mitochondrial large ribosomal subunit

nuclear protein-containing complex [inference]

microprocessor complex

intracellular protein-containing complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

ribonuclease III complex [inference]

microprocessor complex

catalytic complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

ribonuclease III complex [inference]

microprocessor complex

ribonucleoprotein complex [inference]

ribosomal subunit [inference]

large ribosomal subunit [inference]

organellar large ribosomal subunit [inference]

mitochondrial large ribosomal subunit

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

nuclear body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22681889
double-stranded RNA binding	IEA
endonuclease activity
ribonuclease III activity	IMR	11551941
ribonuclease III activity	IKR	11551941

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

ribonuclease III activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

ribonuclease III activity

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

ribonuclease III activity

double-stranded RNA-specific ribonuclease activity [inference]

ribonuclease III activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

double-stranded RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ribosomal protein L44, mitochondrial

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
acyltransferase activity, transferring groups other than amino-acyl groups
cysteine biosynthetic process from serine
homoserine O-acetyltransferase activity
homoserine metabolic process
methionine biosynthetic process
serine O-acetyltransferase activity

Displaying **all 3** entries
InterPro
Alpha/Beta hydrolase fold
Alpha/beta hydrolase fold-1
Homoserine/serine acetyltransferase MetX-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111469	combined oxidative phosphorylation deficiency 16	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	65080	Xenbase:XB-GENE-1000272
Mus musculus	69163		MOUSE27424
Rattus norvegicus	301552		RATNO43141
Pan troglodytes	470663		PANTR29896
Bos taurus	532389		BOVIN24839
Danio rerio	571210		DANRE09306
Macaca mulatta	677716		MACMU06176
Monodelphis domestica	100022395		MONDO32687
Equus caballus	100056697		HORSE36026
Ornithorhynchus anatinus	100080160		ORNAN24650

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Last updated: April 7, 2025