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MIRAGE
bone morphogenetic protein 2
Summary
- Gene Symbol
-
- BMP2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Chondrogenesis
- Cleavage on pair of basic residues
- Cytokine
- Developmental protein
- Differentiation
- Disease variant
- Disulfide bond
- Dwarfism
- Glycoprotein
- Growth factor
- Osteogenesis
- Pharmaceutical
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| skeletal system development | ||
| osteoblast differentiation | ||
| branching involved in ureteric bud morphogenesis | ||
| response to hypoxia |
GO Hierarchy
- positive regulation of cartilage development
- positive regulation of cartilage development
biological process
metabolic process [inference]
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of hormone biosynthetic process [inference]
regulation of lipid biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of hormone biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of hormone metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of lipid metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
negative regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of cell differentiation [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of signaling [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of response to stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
positive regulation of cell differentiation [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
negative regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of hormone biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
regulation of biological quality [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| plasma membrane | ||
| cilium |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| signaling receptor binding | ||
| cytokine activity | ||
| cytokine activity | ||
| cytokine activity | ||
| protein binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Bone morphogenetic protein 2
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| growth factor activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050591 | tooth agenesis | |
| DOID:0060989 | short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1 | |
| DOID:0110965 | brachydactyly type A2 | |
| DOID:0111029 | hemochromatosis type 1 | |
| DOID:10283 | prostate cancer | |
| DOID:11476 | osteoporosis | |
| DOID:12185 | otosclerosis | |
| DOID:8398 | osteoarthritis |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 778554 | CIOIN07113 | ||
| 100031674 | MONDO08803 | ||
| 100051701 | HORSE21223 | ||
| 100084030 | ORNAN26891 | ||
| 100157103 | PIGXX11236 | ||
| 100218108 | TAEGU22247 | ||
| 100301987 | FELCA06363 | ||
| 100408260 | CALJA32713 | ||
| 100460853 | PONAB20732 | ||
| 100465860 | AILME06804 |
