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bone morphogenetic protein 3

Summary

Gene Symbol

BMP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

651

PubChem

651

Alliance of Genome Resources

HGNC:1070

Annotation

Keyword

3D-structure
Chondrogenesis
Cleavage on pair of basic residues
Cytokine
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Growth factor
Osteogenesis
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P12645	Bone morphogenetic protein 3A Osteogenin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
skeletal system development	TAS	3201241
osteoblast differentiation	IEA
signal transduction	IEA
cell-cell signaling	TAS	3201241
negative regulation of ossification	IDA	15269709

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cartilage development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of cellular process [inference]

signal transduction

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

negative regulation of ossification

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
extracellular exosome	HDA	19199708

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signaling receptor binding	TAS	3201241
cytokine activity	IBA
growth factor activity	IEA
BMP receptor binding	IDA	7811286

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

receptor serine/threonine kinase binding [inference]

transmembrane receptor protein serine/threonine kinase binding [inference]

BMP receptor binding

receptor ligand activity [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

bone morphogenetic protein 3

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cytokine activity
growth factor activity
osteoblast differentiation
positive regulation of osteoblast differentiation

Displaying **all 4** entries
InterPro
Cystine-knot cytokine
Transforming growth factor beta, conserved site
Transforming growth factor-beta, C-terminal
Transforming growth factor-beta-related

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	651	Xenbase:XB-GENE-483484
Rattus norvegicus	25667	Xenbase:XB-GENE-483484	RATNO08341
Mus musculus	110075	Xenbase:XB-GENE-483484	MOUSE46088
Xenopus tropicalis	177719	Xenbase:XB-GENE-483484
Xenopus tropicalis	399354	Xenbase:XB-GENE-483484
Pan troglodytes	471189		PANTR33649
Bos taurus	539527		BOVIN31747
Macaca mulatta	695432		MACMU36400
Danio rerio	777717		DANRE36799
Monodelphis domestica	100018204		MONDO27838