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solute carrier family 2 member 3

Summary

Gene Symbol

SLC2A3

Organism

Homo sapiens (human)

External Links

NCBI Gene

6515

HGNC

11007

KEGG Gene ID

hsa:6515

PubChem

6515

Alliance of Genome Resources

HGNC:11007

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Glycoprotein
Phosphoprotein
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P11169	Glucose transporter type 3, brain

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
dehydroascorbic acid transport	IBA
glucose transmembrane transport	IDA	26176916 8457197
fructose transmembrane transport	IDA	8457197
galactose transmembrane transport	IDA	8457197
carbohydrate metabolic process	NAS	1695905

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic anion transport [inference]

dehydroascorbic acid transport

import into cell [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

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GO Term	Evidence Code	PMID
ficolin-1-rich granule membrane	TAS
plasma membrane	IBA IDA IMP ISS TAS	9477959
cell projection	IEA
membrane	IDA	26176916
aggresome	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
galactose transmembrane transporter activity	IDA	8457197
glucose transmembrane transporter activity	IDA	26176916
glucose binding	IDA	26176916
D-glucose transmembrane transporter activity	IBA IDA	8457197
protein binding	IPI	32296183 35810171

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

glucose binding

small molecule binding [inference]

monosaccharide binding [inference]

glucose binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000059804

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K08142

Name

MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 3

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0110746	type 1 diabetes mellitus 7	DisGeNET
DOID:0050328	congenital hypothyroidism	DisGeNET
DOID:0050424	familial adenomatous polyposis	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060058	lymphoma	DisGeNET
DOID:0060224	atrial fibrillation	DisGeNET
DOID:0060326	myelomeningocele	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000496	Abnormality of eye movement
HP:0000713	Agitation
HP:0000716	Depression
HP:0000718	Aggressive behavior
HP:0000722	Compulsive behaviors
HP:0000734	Disinhibition
HP:0000737	Irritability
HP:0000738	Hallucinations
HP:0000739	Anxiety
HP:0000741	Apathy

Displaying 1 entry
Disease ID	Disease Name
ORPHA:399	Huntington disease

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	173525	WB:WBGene00019207
Caenorhabditis elegans	178634	WB:WBGene00019979
Drosophila melanogaster	38109	FB:FBgn0264574
Ciona intestinalis	100185344		CIOIN12582
Danio rerio	436916	ZFIN:ZDB-GENE-040718-390	DANRE15073
Danio rerio	100330897	ZFIN:ZDB-GENE-121031-5
Astyanax mexicanus	103021572		ASTMX11493
Ictalurus punctatus	108273342		ICTPU03793
Electrophorus electricus	113576318		ELEEL18515
Salmo salar	106569997		SALSA34528

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UniCarb-DR

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements