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solute carrier family 2 member 4

Summary

Gene Symbol

SLC2A4

Organism

Homo sapiens (human)

External Links

NCBI Gene

6517

HGNC

11009

KEGG Gene ID

hsa:6517

PubChem

6517

Alliance of Genome Resources

HGNC:11009

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytoplasm
Diabetes mellitus
Disease variant
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Sugar transport
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P14672	Glucose transporter type 4, insulin-responsive

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
glucose import	IBA NAS	11742412
positive regulation of brain-derived neurotrophic factor receptor signaling pathway	ISS
regulation of synaptic vesicle budding from presynaptic endocytic zone membrane	IEA
glucose import in response to insulin stimulus	ISS
response to ethanol	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amylopectin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amylopectin biosynthetic process

carbohydrate derivative biosynthetic process [inference]

amylopectin biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amylopectin biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

amylopectin biosynthetic process

amylopectin metabolic process [inference]

amylopectin biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

amylopectin biosynthetic process

amylopectin metabolic process [inference]

amylopectin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amylopectin biosynthetic process

carbohydrate derivative biosynthetic process [inference]

amylopectin biosynthetic process

cellular process [inference]

cell population proliferation [inference]

fat cell proliferation [inference]

white fat cell proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amylopectin biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport

glucose import

glucose import in response to insulin stimulus

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

nervous system process [inference]

cognition [inference]

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to osmotic stress [inference]

cellular response to osmotic stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to hypoxia

response to abiotic stimulus [inference]

response to osmotic stress [inference]

cellular response to osmotic stress

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to alcohol [inference]

response to ethanol

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

response to peptide [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport

glucose import

glucose import in response to insulin stimulus

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport

glucose import

glucose import in response to insulin stimulus

organic anion transport [inference]

dehydroascorbic acid transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of synaptic vesicle budding from presynaptic endocytic zone membrane

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
vesicle membrane	IDA	14562105
external side of plasma membrane	IDA	14562105
multivesicular body	IEA
membrane	TAS	2649253
insulin-responsive compartment	IDA ISS	19590752

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane

cytoplasmic vesicle membrane

plasma membrane region [inference]

clathrin-coated pit

membrane microdomain [inference]

membrane raft

T-tubule

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

presynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19478182 25910212 33961781
glucose uniporter activity	ISS
glucose transmembrane transporter activity
D-glucose transmembrane transporter activity	IBA IDA ISS	25004245

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity

hexose uniporter activity [inference]

glucose uniporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

uniporter activity [inference]

hexose uniporter activity [inference]

glucose uniporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 2

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
Glucose transporter GLUT
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like
Sugar transporter, conserved site
Sugar/inositol transporter

Human Protein Atlas

ENSG00000181856

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07191

Name

MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4

References

Ortholog

Displaying entries **61 - 70** of 95 in total

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Species	Gene ID	Orthologous MAtrix
Mandrillus leucophaeus	105549897	MANLE14820
Cercocebus atys	105582615	CERAT16988
Aotus nancymaae	105720778	AOTNA32879
Propithecus coquereli	105819426	PROCO25616
Microcebus murinus	105877856	MICMU05611
Dipodomys ordii	105983532	DIPOR08588
Equus asinus asinus	106844181	EQUAS23814
Cyprinodon variegatus	107087738	CYPVA10924
Sinocyclocheilus grahami	107565717	SINGR90894
Kryptolebias marmoratus	108251468	KRYMA28596

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements