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solute carrier family 3 member 2

Summary

Gene Symbol

SLC3A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6520

PubChem

6520

Alliance of Genome Resources

HGNC:11026

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Amino-acid transport
Cell junction
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Isopeptide bond
Lysosome
Phosphoprotein
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P08195	4F2 cell-surface antigen heavy chain 4F2 heavy chain antigen Lymphocyte activation antigen 4F2 large subunit Solute carrier family 3 member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
calcium ion transport	NAS	3036867
amino acid transport	TAS	10673541
isoleucine transport	IDA	11311135 11557028
leucine transport	IDA	10574970 11557028 11564694 12225859 15769744 9751058

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

cellular process [inference]

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to dsRNA [inference]

response to exogenous dsRNA

response to nitrogen compound [inference]

response to dsRNA [inference]

response to exogenous dsRNA

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

hormone transport [inference]

thyroid hormone transport

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic substance transport [inference]

calcium ion transport

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport

sulfur amino acid transport [inference]

methionine transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

aromatic amino acid transport [inference]

basic amino acid transport [inference]

histidine transport [inference]

L-histidine transport

branched-chain amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

valine transport

neutral amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

alanine transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-histidine transport

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

phenylalanine transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport

sulfur amino acid transport [inference]

methionine transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

aromatic amino acid transport [inference]

basic amino acid transport [inference]

histidine transport [inference]

L-histidine transport

branched-chain amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

valine transport

neutral amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

alanine transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-histidine transport

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

phenylalanine transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

nitrogen compound transport [inference]

amino acid transport

sulfur amino acid transport [inference]

methionine transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

aromatic amino acid transport [inference]

basic amino acid transport [inference]

histidine transport [inference]

L-histidine transport

branched-chain amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

valine transport

neutral amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

alanine transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-histidine transport

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

phenylalanine transport

sulfur compound transport [inference]

sulfur amino acid transport [inference]

methionine transport

import into cell [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

thyroid hormone transport

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
lysosomal membrane	IEA
plasma membrane	TAS
plasma membrane	IDA	11311135 11557028 12225859 12270127 23137377 25998567 28112518
basal plasma membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

amino acid transport complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

cell junction [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell pole [inference]

apical pole of neuron

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
virus receptor activity	IEA
RNA binding	HDA	22658674
double-stranded RNA binding	IDA	21266579
neutral L-amino acid secondary active transmembrane transporter activity
calcium:sodium antiporter activity

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

aromatic amino acid transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

branched-chain amino acid transmembrane transporter activity [inference]

L-leucine transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

aromatic amino acid transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

branched-chain amino acid transmembrane transporter activity [inference]

L-leucine transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

neutral L-amino acid secondary active transmembrane transporter activity

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

cell adhesion molecule binding [inference]

cadherin binding

exogenous protein binding

virus receptor activity

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

double-stranded RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

4F2 cell-surface antigen heavy chain

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
L-alanine import across plasma membrane
L-alanine transmembrane transporter activity
L-leucine transmembrane transporter activity
aromatic amino acid transmembrane transporter activity
phenylalanine transport

Displaying **all 5** entries
InterPro
Amino acid transporter heavy chain SLC3A2
Glycoside hydrolase superfamily
Glycosyl hydrolase, all-beta
Glycosyl hydrolase, family 13, catalytic domain
Solute carrier family 3 member 2, N-terminal domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements