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Guidelines
MIRAGE
protein kinase AMP-activated catalytic subunit alpha 1

Summary
Gene Symbol
  • Prkaa1
Organism
Rattus norvegicus (Norway rat)
NCBI Gene
65248
PubChem
65248
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Autophagy
  • Biological rhythms
  • Cholesterol biosynthesis
  • Chromatin regulator
  • Cytoplasm
  • Direct protein sequencing
  • Fatty acid biosynthesis
  • Glycoprotein
  • Magnesium
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Serine/threonine-protein kinase
  • Transcription regulation
  • Ubl conjugation
  • Wnt signaling pathway
Proteins
Displaying 1 entry
UniProt Protein Name
P54645
  • Acetyl-CoA carboxylase kinase
  • Hydroxymethylglutaryl-CoA reductase kinase
  • Tau-protein kinase PRKAA1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 92 in total
GO Term Evidence Code PMID
positive regulation of T cell mediated immune response to tumor cell
glucose metabolic process
chromatin organization
chromatin remodeling
protein phosphorylation
GO Hierarchy
Displaying entries 1 - 5 of 39 in total
GO Term Evidence Code PMID
chromatin binding
chromatin binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine kinase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Rodentia
Group Name
5'-AMP-activated protein kinase catalytic subunit alpha-1
Functional Category
  • I: Lipid transport and metabolism
  • J: Translation, ribosomal structure and biogenesis
  • T: Signal transduction mechanisms
Displaying entries 1 - 10 of 12 in total
Gene Ontology
AMP-activated protein kinase activity
ATP binding
cholesterol biosynthetic process
cholesterol metabolic process
kinase activity
nucleotide binding
phosphorylation
positive regulation of cellular catabolic process
rhythmic process
steroid biosynthetic process
Displaying all 8 entries
InterPro
5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal
AMPK, C-terminal adenylate sensor domain
KA1 domain/Ssp2, C-terminal
PRKAA1, UBA-like autoinhibitory domain
PRKAA1/2, autoinhibitory domain
Protein kinase domain
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site
Alliance of Genome Resources
Expression
Displaying all 4 entries
Location References
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:9352 type 2 diabetes mellitus
Ortholog
Displaying entries 1 - 10 of 69 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
5562 Xenbase:XB-GENE-946195 HUMAN78984
5563 SGD:S000002885
65248 Xenbase:XB-GENE-946195
105787 Xenbase:XB-GENE-946195 MOUSE15021
108079 SGD:S000002885
540404 BOVIN16009
695558 MACMU39802
696436 MACMU39802
100001198 DANRE37218
100013711 MONDO18309
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025