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histo-blood group ABO system transferase 3

Summary

Gene Symbol

Abo3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

65270

KEGG Gene ID

rno:65270

PubChem

65270

Alliance of Genome Resources

RGD:628609

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ET32	Blood group A glycosyltransferase 1 Cis-AB transferase 1 Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-galactosyltransferase Histo-blood group A transferase Histo-blood group B transferase N-acetylgalactosaminyltransferase A blood group-like enzyme NAGAT 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein glycosylation	IEA
defense response to bacterium	IEP	11842091
carbohydrate metabolic process	IEA
lipid glycosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

lipid glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IEA
Golgi apparatus	IBA
extracellular region	IEA
vesicle	IBA
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	IBA IDA	11842091
fucosylgalactoside 3-alpha-galactosyltransferase activity	IEA
metal ion binding	IEA
hexosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

hexosyltransferase activity

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

histo-blood group ABO system transferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
hexosyltransferase activity
lipid glycosylation
metal ion binding
transferase activity

Displaying **all 2** entries
InterPro
Glycosyl transferase, family 6
Nucleotide-diphospho-sugar transferases

KEGG BRITE Database

Orthology

K00709

Name

histo-blood group ABO system transferase [EC:2.4.1.40 2.4.1.37]

References

12180981

Reactions

Displaying **all 9** entries
KEGG Reaction	Enzyme	Acceptor	Product
R06191	2.4.1.40	G59724US	G20578GS
R06193	2.4.1.40	G66427ZQ	G46461VY
R06029	2.4.1.37	G13636IT	G77593JU
R06197	2.4.1.40	G58990QD	G51661GQ
R06187	2.4.1.40	G13636IT	G96538JO
R06167	2.4.1.40	G00050MO	G82858KU
R06190	2.4.1.37	G66427ZQ	G47614ZH
R13171	2.4.1.40	G98465JN	G37830TX
R06168	2.4.1.37	G00050MO	G63238VS

Rhea

RHEA:19021

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-N-acetyl-α-D-galactosamine

an N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.40

PMID

RHEA:14349

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-α-D-galactose

an α-D-galactosyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.37

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1240	leukemia	Alliance of Genome Resources
DOID:13406	pulmonary sarcoidosis	Alliance of Genome Resources
DOID:14067	Plasmodium falciparum malaria	Alliance of Genome Resources
DOID:1496	echinococcosis	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2237	hepatitis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012733
Gene Name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	28		HGNC:79	HUMAN99108
Mus musculus	80908	10090_1:00095e	MGI:2135738	MOUSE35804
Danio rerio	387303		ZFIN:ZDB-GENE-031204-4
Danio rerio	393300		ZFIN:ZDB-GENE-040426-1117
Danio rerio	447881		ZFIN:ZDB-GENE-040912-46
Xenopus tropicalis	549437		Xenbase:XB-GENE-5962599
Xenopus tropicalis	549858		Xenbase:XB-GENE-969944
Xenopus tropicalis	550054		Xenbase:XB-GENE-5721534
Danio rerio	563897		ZFIN:ZDB-GENE-080402-11
Danio rerio	566487		ZFIN:ZDB-GENE-060531-71

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements