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solute carrier family 12 member 3

Summary

Gene Symbol

SLC12A3

Organism

Homo sapiens (human)

External Links

NCBI Gene

6559

PubChem

6559

Alliance of Genome Resources

HGNC:10912

JoGo

SLC12A3

TogoVar

SLC12A3

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Chloride
Disease variant
Disulfide bond
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Sodium transport
Symport
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P55017	Na-Cl cotransporter Na-Cl symporter Thiazide-sensitive sodium-chloride cotransporter
J3QSS1	Na-Cl symporter Thiazide-sensitive sodium-chloride cotransporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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2

3

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GO Term	Evidence Code	PMID
response to dietary excess	IEA
monoatomic ion transport	TAS
ion transport	TAS
sodium ion transport	ISS
cell volume homeostasis	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal sodium ion transport [inference]

renal sodium ion absorption

renal absorption [inference]

renal sodium ion absorption

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

monoatomic anion homeostasis [inference]

chloride ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to dietary excess

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid [inference]

response to aldosterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid [inference]

response to aldosterone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid [inference]

response to aldosterone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid [inference]

response to aldosterone

response to alcohol [inference]

response to aldosterone

response to ketone [inference]

response to aldosterone

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to aldosterone

response to ketone [inference]

response to aldosterone

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport

renal sodium ion transport [inference]

renal sodium ion absorption

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytosol	IEA
plasma membrane	TAS
plasma membrane	IDA	22009145 36370249
membrane	TAS	8670281
apical plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	22406640
ATP binding	IEA
sodium:potassium:chloride symporter activity	IBA
sodium:chloride symporter activity	TAS
sodium:chloride symporter activity	IDA	18270262 36351028 36792826

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 12 member

Functional Category

E: Amino acid transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
cell volume homeostasis
chloride ion homeostasis
chloride transmembrane transport
chloride
monoatomic ion transport
potassium ion homeostasis
sodium ion homeostasis
sodium

Displaying **all 4** entries
InterPro
Amino acid permease, N-terminal
Amino acid permease/ SLC12A domain
SLC12A transporter family
SLC12A transporter, C-terminal

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050450	Gitelman syndrome	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements