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solute carrier family 34 member 1

Summary

Gene Symbol

SLC34A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6569

PubChem

6569

Alliance of Genome Resources

HGNC:11019

Annotation

Keyword

Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Osteoporosis
Phosphoprotein
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q86VN6	Na(+)-dependent phosphate cotransporter 2A Sodium/phosphate cotransporter 2A Solute carrier family 34 member 1
Q06495	Na(+)-dependent phosphate cotransporter 2A NaPi-3 Sodium/phosphate cotransporter 2A Solute carrier family 34 member 1
Q7Z725	Na(+)-dependent phosphate cotransporter 2A Sodium/phosphate cotransporter 2A Solute carrier family 34 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
ossification	IEA
kidney development	IEA
phosphate ion transport	IDA	8327470 8898024 9530108
glycoprotein metabolic process	IEA
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

indole-containing compound metabolic process [inference]

indole metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process

cellular aromatic compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

gentamycin metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

aminoglycoside antibiotic metabolic process [inference]

gentamycin metabolic process

organic cyclic compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

indole-containing compound metabolic process [inference]

indole metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

gentamycin metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process

cellular aromatic compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

arsenate ion transmembrane transport

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth [inference]

dentinogenesis

anatomical structure formation involved in morphogenesis [inference]

dentinogenesis

anatomical structure development [inference]

animal organ development [inference]

kidney development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular phosphate ion homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular phosphate ion homeostasis

inorganic ion homeostasis [inference]

phosphate ion homeostasis

intracellular phosphate ion homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin A

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

response to peptide hormone [inference]

response to growth hormone

response to parathyroid hormone [inference]

cellular response to parathyroid hormone stimulus

response to thyroid hormone

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin A

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

response to peptide hormone [inference]

response to growth hormone

response to parathyroid hormone [inference]

cellular response to parathyroid hormone stimulus

response to thyroid hormone

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to peptide

response to peptide hormone [inference]

response to growth hormone

response to organic cyclic compound [inference]

response to estradiol

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

response to lipid [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to inorganic substance [inference]

response to metal ion [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to peptide

response to peptide hormone [inference]

response to growth hormone

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to oxygen-containing compound [inference]

response to peptide

response to peptide hormone [inference]

response to growth hormone

response to salt [inference]

response to potassium ion

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic anion transport [inference]

phosphate ion transport

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

arsenate ion transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of phosphate transport [inference]

regulation of sodium-dependent phosphate transport [inference]

positive regulation of sodium-dependent phosphate transport

regulation of phosphate transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of inorganic anion transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of phosphate transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of sodium-dependent phosphate transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of sodium-dependent phosphate transport

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of inorganic anion transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of phosphate transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of biological quality [inference]

regulation of membrane potential [inference]

positive regulation of membrane potential

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
endosome	IEA
cytosol	IDA
plasma membrane	NAS	8327470
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

perinuclear region of cytoplasm

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
sodium:phosphate symporter activity	TAS
sodium:phosphate symporter activity	IDA	8327470 8898024 9530108
sodium:phosphate symporter activity	IMP	12324554 20335586 26047794
sodium:phosphate symporter activity	IBA
protein binding	IPI	17895247 22506049

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

binding [inference]

protein binding

protein domain specific binding [inference]

PDZ domain binding

identical protein binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium-dependent phosphate transporter

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
intracellular phosphate ion homeostasis
sodium ion transmembrane transport
sodium-dependent phosphate transport

Displaying 1 entry
InterPro
Sodium-dependent phosphate transport protein

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050947	hereditary hypophosphatemic rickets with hypercalciuria	Alliance of Genome Resources
DOID:0080077	hypophosphatemic nephrolithiasis/osteoporosis 1	Alliance of Genome Resources
DOID:0080758	Fanconi renotubular syndrome 2	Alliance of Genome Resources
DOID:1062	Fanconi syndrome	Alliance of Genome Resources
DOID:12678	hypercalcemia	Alliance of Genome Resources
DOID:585	nephrolithiasis	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	6569	ZFIN:ZDB-GENE-101006-4
Caenorhabditis elegans	10568	WB:WBGene00022767
Mus musculus	20505	ZFIN:ZDB-GENE-101006-3	MOUSE11423
Caenorhabditis elegans	20531	WB:WBGene00022767
Rattus norvegicus	25548	ZFIN:ZDB-GENE-101006-3	RATNO12131
Caenorhabditis elegans	84395	WB:WBGene00022767
Caenorhabditis elegans	142680	WB:WBGene00022767
Caenorhabditis elegans	142681	WB:WBGene00022767
Caenorhabditis elegans	246234	WB:WBGene00022767
Bos taurus	282483		BOVIN33171

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Acknowledgements