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MIRAGE

ADAM metallopeptidase with thrombospondin type 1 motif, 4

Summary

Gene Symbol

Adamts4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

66015

PubChem

66015

Alliance of Genome Resources

RGD:621242

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ESP7	Aggrecanase-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteolysis	ISO
proteolysis	IBA
proteolysis	IEA
extracellular matrix organization	IBA
extracellular matrix organization	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IEA
nuclear speck	ISO
nuclear speck	IEA
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

nuclear body [inference]

nuclear speck

external encapsulating structure [inference]

extracellular matrix

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protease binding	ISO
protease binding	IEA
metalloendopeptidase activity	ISO
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Thrombospondin

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
extracellular matrix organization
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 8** entries
InterPro
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
ADAMTS/ADAMTS-like, cysteine-rich domain 3
ADAMTS/ADAMTS-like
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6476	Xenbase:XB-GENE-996659
Xenopus tropicalis	8972	Xenbase:XB-GENE-996659
Homo sapiens	9507	Xenbase:XB-GENE-996659	HUMAN53168
Drosophila melanogaster	11095	FB:FBgn0286071
Drosophila melanogaster	56999	FB:FBgn0286071
Xenopus tropicalis	66015	Xenbase:XB-GENE-996659
Xenopus tropicalis	69983	Xenbase:XB-GENE-996659
Drosophila melanogaster	79252	FB:FBgn0286071
Drosophila melanogaster	80070	FB:FBgn0286071
Xenopus tropicalis	93432	Xenbase:XB-GENE-996659

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Last updated: April 7, 2025