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SEC61 translocon subunit beta

Summary

Gene Symbol

Sec61b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

66212

PubChem

66212

Alliance of Genome Resources

MGI:1913462

Annotation

Keyword

Acetylation
Direct protein sequencing
Endoplasmic reticulum
Palmitate
Phosphoprotein
Reference proteome
Translocation
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9CQS8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
SRP-dependent cotranslational protein targeting to membrane, translocation	IBA
retrograde protein transport, ER to cytosol	ISO
retrograde protein transport, ER to cytosol	IEA
post-translational protein targeting to membrane, translocation	IBA
ERAD pathway	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

intracellular protein transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO
endoplasmic reticulum	IDA	23093945 23439682
Sec61 translocon complex	IBA
Sec61 translocon complex	IEA
endoplasmic reticulum membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

translocon complex [inference]

Sec61 translocon complex

endoplasmic reticulum protein-containing complex [inference]

translocon complex [inference]

Sec61 translocon complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

endoplasmic reticulum quality control compartment

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IBA
protein binding	IPI	11408579
ribosome binding	ISO
ribosome binding	IDA	16705175
epidermal growth factor binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

growth factor binding [inference]

epidermal growth factor binding

hormone binding [inference]

epidermal growth factor binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transport protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
SRP-dependent cotranslational protein targeting to membrane, translocation
post-translational protein targeting to membrane, translocation

Displaying **all 2** entries
InterPro
Protein transport Sec61-beta/Sbh
Protein transport protein SecG/Sec61-beta/Sbh

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10952	Xenbase:XB-GENE-493431	HUMAN97807
Xenopus tropicalis	66212	Xenbase:XB-GENE-493431
Rattus norvegicus	298068		RATNO34310
Canis lupus familiaris	404018		CANLF02359
Bos taurus	506986		BOVIN34652
Macaca mulatta	717815		MACMU11869
Pan troglodytes	747589		PANTR44463
Danio rerio	791986		DANRE11102
Monodelphis domestica	100011332		MONDO29206
Ciona intestinalis	100175466		CIOIN10876