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small nuclear ribonucleoprotein polypeptide E

Summary

Gene Symbol

SNRPE

Organism

Homo sapiens (human)

External Links

NCBI Gene

6635

PubChem

6635

Alliance of Genome Resources

HGNC:11161

Annotation

Keyword

3D-structure
Cytoplasm
Disease variant
Hypotrichosis
Nucleus
RNA-binding
Reference proteome
Ribonucleoprotein
Spliceosome

Proteins

Displaying 1 entry
UniProt	Protein Name
P62304	Sm protein E

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
mRNA splicing, via spliceosome	IDA	28076346 32494006 36797247
7-methylguanosine cap hypermethylation	NAS	15564372
U2-type prespliceosome assembly	NAS	31744343

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

methylation [inference]

macromolecule methylation [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

macromolecule methylation [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

RNA capping [inference]

7-methylguanosine cap hypermethylation

RNA modification [inference]

RNA methylation [inference]

7-methylguanosine cap hypermethylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly

U2-type prespliceosome assembly

spliceosomal snRNP assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly

U2-type prespliceosome assembly

spliceosomal snRNP assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly

U2-type prespliceosome assembly

spliceosomal snRNP assembly

Displaying entries **21 - 25** of 34 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA	18984161
small nuclear ribonucleoprotein complex	NAS	2974536
methylosome	IDA	18984161
pICln-Sm protein complex	IDA	18984161

GO Hierarchy

cellular component

protein-containing complex [inference]

Sm-like protein family complex [inference]

small nuclear ribonucleoprotein complex

U7 snRNP

spliceosomal snRNP complex [inference]

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

nuclear protein-containing complex [inference]

spliceosomal complex

U2-type spliceosomal complex

U12-type spliceosomal complex

precatalytic spliceosome

U2-type precatalytic spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

telomerase holoenzyme complex

small nuclear ribonucleoprotein complex

U7 snRNP

spliceosomal snRNP complex [inference]

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

catalytic complex [inference]

telomerase holoenzyme complex

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

transferase complex [inference]

methyltransferase complex [inference]

methylosome

ribonucleoprotein complex [inference]

spliceosomal complex

U2-type spliceosomal complex

U12-type spliceosomal complex

precatalytic spliceosome

U2-type precatalytic spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

telomerase holoenzyme complex

small nuclear ribonucleoprotein complex

U7 snRNP

spliceosomal snRNP complex [inference]

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
RNA binding	IEA
protein binding	IPI	10500148 11714716 11748230 12065586 14667819 15231747 15939020 17332742 18984161 22365833 28514442 30021884 31799625 32296183 33961781 35271311 9417867

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

small nuclear ribonucleoprotein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0110698	hypotrichosis 1	Alliance of Genome Resources
DOID:0110708	hypotrichosis 11	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6635	Xenbase:XB-GENE-5922245
Mus musculus	20643		MOUSE29236
Danio rerio	393979		DANRE02210
Felis catus	493770		FELCA36425
Pan troglodytes	741566		PANTR23426
Monodelphis domestica	100012867		MONDO09564
Sus scrofa	100038330		PIGXX35868
Salmo salar	100195665		SALSA83595
Rattus norvegicus	100360682		RATNO40418
Rattus norvegicus	100362099		RATNO21344