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Guidelines

MIRAGE

superoxide dismutase 2

Summary

Gene Symbol

SOD2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6648

PubChem

6648

Alliance of Genome Resources

HGNC:11180

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Manganese
Metal-binding
Mitochondrion
Nitration
Oxidoreductase
Proteomics identification
Reference proteome
Transit peptide
Ubl conjugation

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A384NL29
G5E9P6
Q96AM7
P04179
Q9UG59

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 57 in total

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GO Term	Evidence Code	PMID
response to superoxide	IMP	16179351
response to hypoxia	IEA
release of cytochrome c from mitochondria	ISS
liver development	IEA
detection of oxygen	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic substance metabolic process [inference]

glutathione metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

pigment cell differentiation [inference]

erythrophore differentiation

cell development [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

apoptotic mitochondrial changes [inference]

release of cytochrome c from mitochondria

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation [inference]

acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure

behavior [inference]

locomotory behavior

post-embryonic development

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

animal organ development [inference]

heart development

gland development [inference]

liver development

cellular developmental process [inference]

cell differentiation [inference]

pigment cell differentiation [inference]

erythrophore differentiation

cell development [inference]

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular oxygen homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

multicellular organismal-level iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular oxygen homeostasis

inorganic ion homeostasis [inference]

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to oxygen radical [inference]

response to superoxide

response to hydrogen peroxide

cellular response to oxidative stress

response to wounding [inference]

response to axon injury

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to L-ascorbic acid

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

response to gamma radiation

response to electrical stimulus

response to oxygen levels [inference]

detection of oxygen

response to decreased oxygen levels [inference]

response to hypoxia

response to increased oxygen levels [inference]

response to hyperoxia

response to magnetism

response to activity

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to L-ascorbic acid

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to organic cyclic compound [inference]

response to L-ascorbic acid

response to lipid [inference]

response to lipopolysaccharide

response to hydrogen peroxide

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to alcohol [inference]

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

response to inorganic substance [inference]

response to oxygen radical [inference]

response to superoxide

response to metal ion [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to oxygen radical [inference]

response to superoxide

response to hydrogen peroxide

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to alcohol [inference]

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to salt [inference]

response to L-ascorbic acid

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of oxygen

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to organic substance [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of smooth muscle cell apoptotic process [inference]

positive regulation of vascular associated smooth muscle cell apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

negative regulation of membrane hyperpolarization

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of fibroblast proliferation [inference]

negative regulation of fibroblast proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of smooth muscle cell apoptotic process [inference]

positive regulation of vascular associated smooth muscle cell apoptotic process

regulation of smooth muscle cell apoptotic process [inference]

positive regulation of smooth muscle cell apoptotic process [inference]

positive regulation of vascular associated smooth muscle cell apoptotic process

regulation of vascular associated smooth muscle cell apoptotic process [inference]

positive regulation of vascular associated smooth muscle cell apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of smooth muscle cell apoptotic process [inference]

positive regulation of vascular associated smooth muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of smooth muscle cell apoptotic process [inference]

positive regulation of vascular associated smooth muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide metabolic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of hydrogen peroxide biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of smooth muscle cell apoptotic process [inference]

positive regulation of vascular associated smooth muscle cell apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cell differentiation involved in phenotypic switching [inference]

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of membrane hyperpolarization [inference]

negative regulation of membrane hyperpolarization

regulation of biological quality [inference]

regulation of blood pressure

negative regulation of blood pressure [inference]

negative regulation of systemic arterial blood pressure [inference]

acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential

regulation of membrane hyperpolarization [inference]

negative regulation of membrane hyperpolarization

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation [inference]

acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

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GO Term	Evidence Code	PMID
mitochondrion	IDA	12551919
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS	10511315
mitochondrial matrix	IDA	23168492

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoid [inference]

mitochondrial nucleoid

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
DNA binding	IEA
superoxide dismutase activity	IDA	12551919 14980699 19265433
superoxide dismutase activity	IBA
protein binding	IPI	32296183
oxygen binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on superoxide radicals as acceptor [inference]

superoxide dismutase activity

binding [inference]

protein binding

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

antioxidant activity [inference]

superoxide dismutase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

superoxide dismutase

Functional Category

L: Replication, recombination and repair
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
oxidoreductase activity
removal of superoxide radicals
superoxide metabolic process

Displaying **all 6** entries
InterPro
Manganese/iron superoxide dismutase, C-terminal domain superfamily
Manganese/iron superoxide dismutase, C-terminal
Manganese/iron superoxide dismutase, N-terminal domain superfamily
Manganese/iron superoxide dismutase, N-terminal
Manganese/iron superoxide dismutase, binding site
Manganese/iron superoxide dismutase

Disease

Disease Ontology

Displaying entries **1 - 10** of 35 in total

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DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1070	primary open angle glaucoma	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10873	Kuhnt-Junius degeneration	Alliance of Genome Resources
DOID:11476	osteoporosis	Alliance of Genome Resources
DOID:11713	diabetic angiopathy	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6648	Xenbase:XB-GENE-1000989
Mus musculus	20656	Xenbase:XB-GENE-1000989	MOUSE21405
Rattus norvegicus	24787	Xenbase:XB-GENE-1000989	RATNO20738
Danio rerio	335799		DANRE19140
Canis lupus familiaris	476258		CANLF00248
Macaca mulatta	574097		MACMU35135
Monodelphis domestica	100032426		MONDO12044
Equus caballus	100034223		HORSE29915
Ornithorhynchus anatinus	100090175		ORNAN15189
Cavia porcellus	100135623		CAVPO18194

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025