GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Disease variant
Flagellum
Membrane
Metal-binding
Mitochondrion
NAD
Neuropathy
Oxidoreductase
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q00796	(R,R)-butanediol dehydrogenase L-iditol 2-dehydrogenase Polyol dehydrogenase Ribitol dehydrogenase Xylitol dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
L-xylitol catabolic process	IDA	8487505
sorbitol catabolic process	IBA IDA IMP	12962626 32367058 3365415 6870831 8487505
glucose metabolic process	TAS	14965227
L-xylitol metabolic process	IDA	3365415
flagellated sperm motility	ISS NAS	16278369

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

glucose metabolic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process [inference]

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

glucose metabolic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process [inference]

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

glucose metabolic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process [inference]

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process [inference]

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
motile cilium	ISS
cytosol	TAS
mitochondrial membrane	IEA
extracellular space	TAS	6177277
membrane	IDA	8487505

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

mitochondrial membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
D-sorbitol dehydrogenase (acceptor) activity	IEA
zinc ion binding	IDA ISS	12962626
NAD binding	IDA	12962626
carbohydrate binding	NAS	12962626
(R,R)-butanediol dehydrogenase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

hexitol dehydrogenase activity [inference]

D-xylulose reductase activity

D-sorbitol dehydrogenase (acceptor) activity

binding [inference]

protein binding [inference]

identical protein binding

carbohydrate binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000140263

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00008

Name

L-iditol 2-dehydrogenase [EC:1.1.1.14]

References

Rhea

RHEA:33031

H⁺ + keto-D-fructose + NADH

D-sorbitol + NAD⁺

Enzyme

1.1.1.14

PMID

RHEA:24340

(R,R)-butane-2,3-diol + NAD⁺

H⁺ + (R)-acetoin + NADH

Enzyme

1.1.1.4

PMID

RHEA:10160

L-iditol + NAD⁺

keto-L-sorbose + H⁺ + NADH

Enzyme

1.1.1.14

PMID

RHEA:20433

xylitol + NAD⁺

H⁺ + D-xylulose + NADH

Enzyme

1.1.1.9

PMID

17216457

RHEA:20053

ribitol + NAD⁺

H⁺ + D-ribulose + NADH

Enzyme

1.1.1.56

PMID

Disease

Disease Ontology

Displaying entries **21 - 30** of **143** in total

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DO ID	Disease Name	Source
DOID:0110233	cataract 27	DisGeNET
DOID:0110234	cataract 4 multiple types	DisGeNET
DOID:0110235	cataract 2 multiple types	DisGeNET
DOID:0110236	cataract 39 multiple types	DisGeNET
DOID:0110237	cataract 42	DisGeNET
DOID:0110238	cataract 18	DisGeNET
DOID:0110239	cataract 12 multiple types	DisGeNET
DOID:0110240	cataract 20 multiple types	DisGeNET
DOID:0110241	cataract 41	DisGeNET
DOID:0110242	cataract 13 with adult i phenotype	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 11 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0001761	Pes cavus
HP:0002355	Difficulty walking
HP:0002495	Impaired vibratory sensation
HP:0002650	Scoliosis
HP:0003431	Decreased motor nerve conduction velocity
HP:0007078	Decreased amplitude of sensory action potentials
HP:0007328	Impaired pain sensation
HP:0008959	Distal upper limb muscle weakness
HP:0008994	Proximal muscle weakness in lower limbs

Displaying 1 entry
Disease ID	Disease Name
OMIM:618912	neuronopathy, distal hereditary motor, autosomal recessive 8

PubChem Disease

MedGen Diseases

Neuronopathy, distal hereditary motor, autosomal recessive 8

OMIM Phenotypes

NEURONOPATHY, DISTAL HEREDITARY MOTOR, AUTOSOMAL RECESSIVE 8; HMNR8

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179404	WB:WBGene00011004
Caenorhabditis elegans	179405	WB:WBGene00011003
Drosophila melanogaster	40836	FB:FBgn0024289
Drosophila melanogaster	41313	FB:FBgn0022359
Ciona intestinalis	100177275		CIOIN13158
Ciona intestinalis	100184593		CIOIN04253
Callorhinchus milii	103188841		CALMI04292
Latimeria chalumnae	102345933		LATCH13849
Danio rerio	570613	ZFIN:ZDB-GENE-040426-1231	DANRE40437
Astyanax mexicanus	103041581		ASTMX14704

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements