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Guidelines

MIRAGE

SOS Ras/Rac guanine nucleotide exchange factor 1

Summary

Gene Symbol

SOS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6654

PubChem

6654

Alliance of Genome Resources

HGNC:11187

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Guanine-nucleotide releasing factor
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07889

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
B cell homeostasis	IEA
hair follicle development	IEA
response to ischemia	IEA
cardiac atrium morphogenesis	IEA
pericardium morphogenesis	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

leukocyte migration

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

cytokine-mediated signaling pathway

neurotrophin signaling pathway [inference]

neurotrophin TRK receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular process involved in reproduction in multicellular organism [inference]

vitellogenesis

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

Schwann cell development

cell motility [inference]

cell migration [inference]

leukocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cytoplasm organization [inference]

vitellogenesis

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

vitellogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

multicellular organism growth

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac atrium morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

embryonic morphogenesis [inference]

pericardium morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an epithelial sheet [inference]

pericardium morphogenesis

trabecula morphogenesis [inference]

heart trabecula morphogenesis

midbrain morphogenesis

anatomical structure development [inference]

hair follicle development

cell development [inference]

glial cell development [inference]

Schwann cell development

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

Schwann cell development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

response to stimulus [inference]

response to stress [inference]

response to ischemia

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of lymphoid progenitor cell differentiation [inference]

regulation of pro-B cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

cytokine-mediated signaling pathway

neurotrophin signaling pathway [inference]

neurotrophin TRK receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cell population proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of lymphoid progenitor cell differentiation [inference]

regulation of pro-B cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

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GO Term	Evidence Code	PMID
cytoplasm	IDA	17515907
cytosol	TAS
plasma membrane	TAS
plasma membrane	IBA
postsynaptic density	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

GTPase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	EXP	1371879 16483568 7731718
guanyl-nucleotide exchange factor activity	TAS
guanyl-nucleotide exchange factor activity	IDA	1371879
guanyl-nucleotide exchange factor activity	IBA
GTPase activator activity	TAS	9790532

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

growth factor receptor binding [inference]

epidermal growth factor receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

SH3 domain binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

molecular condensate scaffold activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

guanine nucleotide exchange factor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
Ras protein signal transduction
small GTPase-mediated signal transduction

Displaying **all 5** entries
InterPro
Ras guanine nucleotide exchange factor domain superfamily
Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Ras guanine-nucleotide exchange factors catalytic domain
Ras-like guanine nucleotide exchange factor, N-terminal
Ras-like guanine nucleotide exchange factor

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060466	gingival fibromatosis	Alliance of Genome Resources
DOID:0060582	Noonan syndrome 4	Alliance of Genome Resources
DOID:1882	atrial heart septal defect	Alliance of Genome Resources
DOID:3490	Noonan syndrome	Alliance of Genome Resources
DOID:6420	pulmonary valve stenosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6654	Xenbase:XB-GENE-1011399
Saccharomyces cerevisiae S288C	6655	SGD:S000004301
Mus musculus	20662		MOUSE22186
Saccharomyces cerevisiae S288C	57139	SGD:S000004301
Rattus norvegicus	313845		RATNO35570
Pan troglodytes	459171		PANTR27462
Bos taurus	537682		BOVIN02276
Macaca mulatta	713777		MACMU08488
Xenopus tropicalis	851019	Xenbase:XB-GENE-1011399
Ornithorhynchus anatinus	100078989		ORNAN12543

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Last updated: April 7, 2025