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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
secreted protein acidic and cysteine rich
Summary
- Gene Symbol
-
- SPARC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Basement membrane
- Calcium
- Copper
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Metal-binding
- Osteogenesis imperfecta
- Reference proteome
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P09486 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of synapse organization | ||
| negative regulation of angiogenesis | ||
| semicircular canal morphogenesis | ||
| regulation of cell morphogenesis | ||
| negative regulation of endothelial cell proliferation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| platelet alpha granule lumen | ||
| platelet alpha granule | ||
| collagen-containing extracellular matrix | ||
| intracellular membrane-bounded organelle | ||
| plasma membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| extracellular matrix structural constituent | ||
| extracellular matrix binding | ||
| collagen binding | ||
| calcium ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- sparc
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| calcium ion binding |
| collagen binding |
| extracellular matrix binding |
| metal ion binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050700 | cardiomyopathy | |
| DOID:0110338 | osteogenesis imperfecta type 17 | |
| DOID:0111535 | progressive osseous heteroplasia | |
| DOID:10976 | membranous glomerulonephritis | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11713 | diabetic angiopathy | |
| DOID:182 | calcinosis | |
| DOID:2152 | ovary epithelial cancer | |
| DOID:2871 | endometrial carcinoma | |
| DOID:2893 | cervix carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 20692 | MGI:98373 | MOUSE05866 | ||
| 24791 | RGD:3742 | RATNO00087 | ||
| 43230 | FB:FBgn0026562 | |||
| 176931 | WB:WBGene00003893 | |||
| 282077 | BOVIN33790 | |||
| 321357 | ZFIN:ZDB-GENE-030131-9 | DANRE07748 | ||
| 379277 | Xenbase:XB-GENE-1009638 | |||
| 379441 | Xenbase:XB-GENE-17342256 | |||
| 394973 | Xenbase:XB-GENE-1009630 | |||
| 445895 | TAKRU09626 |
