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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
secreted protein acidic and cysteine rich
Summary
- Gene Symbol
-
- SPARC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Basement membrane
- Calcium
- Copper
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Metal-binding
- Osteogenesis imperfecta
- Reference proteome
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P09486 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of synapse organization | ||
| negative regulation of angiogenesis | ||
| semicircular canal morphogenesis | ||
| regulation of cell morphogenesis | ||
| negative regulation of endothelial cell proliferation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cell surface | ||
| mitochondrion | ||
| extracellular space | ||
| cytoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| extracellular matrix structural constituent | ||
| extracellular matrix binding | ||
| collagen binding | ||
| calcium ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- sparc
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| calcium ion binding |
| collagen binding |
| extracellular matrix binding |
| metal ion binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050700 | cardiomyopathy | |
| DOID:0110338 | osteogenesis imperfecta type 17 | |
| DOID:0111535 | progressive osseous heteroplasia | |
| DOID:10976 | membranous glomerulonephritis | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11713 | diabetic angiopathy | |
| DOID:182 | calcinosis | |
| DOID:2152 | ovary epithelial cancer | |
| DOID:2871 | endometrial carcinoma | |
| DOID:2893 | cervix carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 100554604 | ANOCA01170 | |||
| 100601804 | NOMLE25552 | |||
| 100675712 | LOXAF20194 | |||
| 100691543 | ORENI46000 | |||
| 100725447 | CAVPO20629 | |||
| 100760092 | CRIGR06033 | |||
| 100855736 | CANLF14899 | |||
| 100860800 | CAPHI27144 | |||
| 100921648 | SARHA08561 | |||
| 100945827 | OTOGA18347 |
