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secreted protein acidic and cysteine rich

Summary

Gene Symbol

SPARC

Organism

Homo sapiens (human)

External Links

NCBI Gene

6678

PubChem

6678

Alliance of Genome Resources

HGNC:11219

Annotation

Keyword

3D-structure
Basement membrane
Calcium
Copper
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Metal-binding
Osteogenesis imperfecta
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P09486	Basement-membrane protein 40 Osteonectin Secreted protein acidic and rich in cysteine

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
regulation of synapse organization	IBA
negative regulation of angiogenesis	IDA	12867428
semicircular canal morphogenesis	IBA
regulation of cell morphogenesis	IDA	15389586
negative regulation of endothelial cell proliferation	IDA	12867428

GO Hierarchy

biological process

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

semicircular canal morphogenesis

embryonic morphogenesis [inference]

semicircular canal morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
platelet alpha granule lumen	TAS
platelet alpha granule	IDA	1737102
collagen-containing extracellular matrix	HDA	28327460
intracellular membrane-bounded organelle	IDA
plasma membrane	IDA TAS	1737102

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

platelet alpha granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

platelet alpha granule membrane

nuclear matrix

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

endocytic vesicle lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18808384 19011090 20926826 3402455
extracellular matrix structural constituent	RCA	28327460
extracellular matrix binding	IBA
collagen binding	IBA IDA	7034958 9501084
calcium ion binding	IBA IDA	7034958

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sparc

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
collagen binding
extracellular matrix binding
metal ion binding

Displaying **all 8** entries
InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
Follistatin-like, N-terminal
Follistatin/Osteonectin EGF domain
Kazal domain superfamily
Kazal domain
Osteonectin-like, conserved site
SPARC/Testican, calcium-binding domain

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:2920	membranoproliferative glomerulonephritis	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	Alliance of Genome Resources
DOID:5517	stomach carcinoma	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9538	multiple myeloma	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 82 in total

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Species	Gene ID	Orthologous MAtrix
Chinchilla lanigera	102021944	CHILA02169
Latimeria chalumnae	102345088	LATCH18842
Myotis lucifugus	102424605	MYOLU05226
Pelodiscus sinensis	102445635	PELSI16089
Callorhinchus milii	103184136	CALMI29073
Chlorocebus sabaeus	103244814	CHLSB11131
Ursus maritimus	103664577	URSMA02370
Nannospalax galili	103749060	NANGA19940
Serinus canaria	103817320	SERCA12418
Rhinopithecus roxellana	104658589	RHIRO29399