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contactin associated protein-like 2

Summary

Gene Symbol

Cntnap2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

66797

PubChem

66797

Alliance of Genome Resources

MGI:1914047

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell junction
Cell projection
Disulfide bond
EGF-like domain
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9CPW0	Cell recognition molecule Caspr2
E9QNF7
Q3SYI6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 89 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IMP	32675284
in utero embryonic development	IMP	32879327
response to dietary excess	IMP	22752552
inflammatory response	IGI	31874168
mitochondrion organization	IMP	28370195

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell adhesion

signal transduction [inference]

intracellular signal transduction

MAPK cascade [inference]

ERK1 and ERK2 cascade

TOR signaling

ensheathment of neurons [inference]

axon ensheathment [inference]

axon ensheathment in central nervous system [inference]

central nervous system myelination

myelination

central nervous system myelination

cell recognition [inference]

neuron recognition

cell population proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

glutamatergic neuron differentiation

fat cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to axon [inference]

protein localization to juxtaparanode region of axon

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

postsynaptic specialization organization [inference]

postsynaptic density organization

cellular component assembly [inference]

cell junction assembly

synapse assembly [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

axonogenesis

dendrite morphogenesis [inference]

dendrite arborization

neuron projection arborization [inference]

dendrite arborization

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection organization [inference]

dendritic spine organization

dendritic spine maintenance

cell junction organization [inference]

cell junction assembly

synapse assembly [inference]

cell junction maintenance [inference]

maintenance of synapse structure

synapse organization [inference]

synapse assembly [inference]

neuromuscular junction development [inference]

neuromuscular junction development, skeletal muscle fiber

maintenance of synapse structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure

dendritic spine maintenance

membrane organization [inference]

neuronal ion channel clustering [inference]

clustering of voltage-gated potassium channels

postsynapse organization [inference]

dendritic spine organization

dendritic spine maintenance

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

transmission of nerve impulse

cognition [inference]

learning or memory [inference]

learning

associative learning

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

neuromuscular process

neuromuscular process controlling posture

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

behavior [inference]

learning or memory [inference]

learning

associative learning

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

rhythmic behavior

circadian behavior [inference]

grooming behavior

locomotory behavior

mechanosensory behavior [inference]

auditory behavior [inference]

vocal learning

multicellular organismal response to stress [inference]

response to pain

multicellular organism growth

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

axonogenesis

dendrite morphogenesis [inference]

dendrite arborization

neuron projection arborization [inference]

dendrite arborization

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal organ development [inference]

embryonic organ development [inference]

embryonic brain development

system development [inference]

limbic system development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

glutamatergic neuron differentiation

fat cell differentiation

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

rhythmic process [inference]

circadian rhythm [inference]

circadian behavior [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to heat

multicellular organismal response to stress [inference]

response to pain

response to external stimulus [inference]

response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to dietary excess

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

response to radiation [inference]

response to light stimulus [inference]

response to light intensity

response to mechanical stimulus

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone

response to organonitrogen compound [inference]

response to metformin

response to cytokine [inference]

response to interleukin-17

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to metformin

response to odorant

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to axon [inference]

protein localization to juxtaparanode region of axon

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to axon [inference]

protein localization to juxtaparanode region of axon

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

positive regulation of biological process [inference]

positive regulation of action potential [inference]

positive regulation of neuronal action potential

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of action potential [inference]

negative regulation of neuronal action potential

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

MAPK cascade [inference]

ERK1 and ERK2 cascade

TOR signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of gap junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of gap junction assembly [inference]

positive regulation of gap junction assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse [inference]

positive regulation of neuronal action potential

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of action potential [inference]

negative regulation of action potential [inference]

negative regulation of neuronal action potential

positive regulation of action potential [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

regulation of biological quality

regulation of membrane potential [inference]

action potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

regulation of action potential [inference]

negative regulation of action potential [inference]

negative regulation of neuronal action potential

positive regulation of action potential [inference]

positive regulation of neuronal action potential

regulation of neuronal action potential [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels

Displaying entries **1 - 5** of 37 in total

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GO Term	Evidence Code	PMID
early endosome	ISS
early endosome	ISO
Golgi apparatus	ISS
Golgi apparatus	ISO
voltage-gated potassium channel complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

plasma membrane raft

synaptic membrane [inference]

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

cell junction [inference]

synapse

excitatory synapse

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar granule cell to Purkinje cell synapse

glutamatergic synapse

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar granule cell to Purkinje cell synapse

GABA-ergic synapse

neuron to neuron synapse [inference]

asymmetric synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar granule cell to Purkinje cell synapse

anchoring junction [inference]

cell-cell junction [inference]

paranodal junction

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

paranode region of axon

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon initial segment

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

juxtaparanode region of axon

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
protease binding
protein binding	IPI	20962216 21632923 25707359 32675284
enzyme binding	ISS
enzyme binding	ISO
PDZ domain binding	IPI	25977097

GO Hierarchy

protease binding

protein domain specific binding [inference]

PDZ domain binding

transmembrane transporter binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

contactin-associated protein-like 2

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like domain
Laminin G domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0090130	cortical dysplasia-focal epilepsy syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	8506	FB:FBgn0013997
Homo sapiens	26047	ZFIN:ZDB-GENE-120328-3	HUMAN91895
Danio rerio	39387	ZFIN:ZDB-GENE-120328-3
Drosophila melanogaster	53321	FB:FBgn0013997
Danio rerio	66797	ZFIN:ZDB-GENE-120328-3
Drosophila melanogaster	79937	FB:FBgn0013997
Drosophila melanogaster	84008	FB:FBgn0013997
Drosophila melanogaster	85445	FB:FBgn0013997
Drosophila melanogaster	129684	FB:FBgn0013997
Drosophila melanogaster	170571	FB:FBgn0013997

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements