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spastin

Summary

Gene Symbol

SPAST

Organism

Homo sapiens (human)

External Links

NCBI Gene

6683

PubChem

6683

Alliance of Genome Resources

HGNC:11233

Annotation

Keyword

3D-structure
ATP-binding
Allosteric enzyme
Alternative initiation
Alternative promoter usage
Alternative splicing
Cell division
Cell projection
Cytoskeleton
Developmental protein
Differentiation
Disease variant
Endoplasmic reticulum
Endosome
Hereditary spastic paraplegia
Isomerase
Lipid droplet
Membrane
Microtubule
Neurogenesis
Nucleus
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E5KRP5
Q9UBP0	Spastic paraplegia 4 protein
E5KRP6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
mitotic cytokinesis	IMP	21310966
microtubule bundle formation	IDA	16219033
endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	19000169
mitotic nuclear membrane reassembly	TAS
axonogenesis	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle disassembly

spindle disassembly [inference]

mitotic spindle disassembly

microtubule severing

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle disassembly

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis

mitotic cytokinesis

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle disassembly

spindle disassembly [inference]

mitotic spindle disassembly

cytokinetic process

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

exit from mitosis

mitotic cell cycle process [inference]

mitotic cytokinesis

mitotic cell cycle phase transition [inference]

exit from mitosis

mitotic nuclear membrane organization [inference]

mitotic nuclear membrane reassembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle disassembly

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle disassembly

spindle disassembly [inference]

mitotic spindle disassembly

microtubule severing

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle disassembly

organelle disassembly [inference]

spindle disassembly [inference]

mitotic spindle disassembly

cellular component disassembly [inference]

organelle disassembly [inference]

spindle disassembly [inference]

mitotic spindle disassembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

membrane assembly [inference]

nuclear membrane reassembly

mitotic nuclear membrane reassembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

membrane organization [inference]

membrane assembly [inference]

nuclear membrane reassembly

mitotic nuclear membrane reassembly

nuclear membrane organization [inference]

nuclear membrane reassembly

mitotic nuclear membrane reassembly

mitotic nuclear membrane organization [inference]

mitotic nuclear membrane reassembly

membrane fission

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle localization [inference]

mitochondrion localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of protein-containing complex disassembly [inference]

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of protein depolymerization [inference]

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of cell division [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
spindle pole	IDA	15269182
nucleus	IDA	15147984 15269182 16026783 19000169
nucleoplasm	IDA
cytoplasm	IDA	16026783 19000169 21545838 23969831
endosome	IDA	19000169

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

organelle membrane [inference]

midbody

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

endoplasmic reticulum tubular network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

intracellular non-membrane-bounded organelle [inference]

lipid droplet

cytoskeleton [inference]

microtubule cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16815977 17389232 18997780 20200447 20719964 22232211 23969831 25390646 26040712 35869491
ATP binding	IEA
microtubule binding	IDA	15716377 16219033 17389232 23745751 34970964
microtubule severing ATPase activity	TAS
microtubule severing ATPase activity	IDA	15716377 16219033 17389232 23745751 26875866

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

isomerase activity

catalytic activity, acting on a protein [inference]

microtubule severing ATPase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule severing ATPase activity

protein-containing complex destabilizing activity [inference]

microtubule severing ATPase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Spastin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
isomerase activity
microtubule cytoskeleton organization
microtubule severing ATPase activity
nucleotide binding

Displaying **all 7** entries
InterPro
AAA ATPase, AAA+ lid domain
AAA+ ATPase domain
ATPase, AAA-type, conserved site
ATPase, AAA-type, core
MIT domain
P-loop containing nucleoside triphosphate hydrolase
Spastin/Vps4, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110792	hereditary spastic paraplegia 4	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6683	Xenbase:XB-GENE-947839
Mus musculus	50850		MOUSE21276
Saccharomyces cerevisiae S288C	55137	SGD:S000000849
Saccharomyces cerevisiae S288C	63979	SGD:S000000849
Rattus norvegicus	362700		RATNO35169
Sus scrofa	396584		PIGXX22297
Danio rerio	405851		DANRE18336
Pan troglodytes	459133		PANTR27369
Bos taurus	521442		BOVIN02193
Canis lupus familiaris	608582		CANLF05026

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Acknowledgements