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Guidelines

MIRAGE

signal recognition particle 72

Summary

Gene Symbol

SRP72

Organism

Homo sapiens (human)

External Links

NCBI Gene

6731

PubChem

6731

Alliance of Genome Resources

HGNC:11303

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Disease variant
Endoplasmic reticulum
Isopeptide bond
Phosphoprotein
Reference proteome
Repeat
Signal recognition particle
TPR repeat
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9HWK0
O76094	Signal recognition particle 72 kDa protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
SRP-dependent cotranslational protein targeting to membrane	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

SRP-dependent cotranslational protein targeting to membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	22541560
signal recognition particle, endoplasmic reticulum targeting	IDA	18089836
signal recognition particle, endoplasmic reticulum targeting	IBA
cytosol	TAS
signal recognition particle	IDA	27899666

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

signal recognition particle

signal recognition particle, endoplasmic reticulum targeting

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 8 in total

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2

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
signal recognition particle binding	IPI	17254600
protein binding	IPI	16672232 24965446 32296183 33961781 35271311
7S RNA binding	IMP	27899666
7S RNA binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

TPR domain binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

7S RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SRP72

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
7S RNA binding
SRP-dependent cotranslational protein targeting to membrane

Displaying **all 5** entries
InterPro
Signal recognition particle subunit SRP72, TPR-like repeat
Signal recognition particle, SRP72 subunit, RNA-binding
Signal recognition particle, SRP72 subunit
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying entries **1 - 10** of 90 in total

1

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6731	Xenbase:XB-GENE-994739
Mus musculus	66661		MOUSE44476
Canis lupus familiaris	403944		CANLF03411
Rattus norvegicus	498351		RATNO07803
Bos taurus	509430		BOVIN31527
Macaca mulatta	694604		MACMU35947
Monodelphis domestica	100012449		MONDO26587
Ciona intestinalis	100182362		CIOIN13735
Oryctolagus cuniculus	100348339		RABIT05413
Callithrix jacchus	100387472		CALJA29066

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Last updated: December 8, 2025