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plakophilin 2

Summary

Gene Symbol

Pkp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

67451

PubChem

67451

Alliance of Genome Resources

MGI:1914701

Annotation

Keyword

Cell adhesion
Cell junction
Cytoplasm
DNA-binding
Methylation
Nucleus
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9CQ73

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **36 - 40** of 40 in total

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GO Term	Evidence Code	PMID
regulation of ventricular cardiac muscle cell action potential	IEA
maintenance of protein localization at cell tip	IMP	35959657
regulation of substrate adhesion-dependent cell spreading	ISO
regulation of substrate adhesion-dependent cell spreading	IEA
regulation of bicellular tight junction assembly	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell-cell signaling involved in cardiac conduction

cell communication involved in cardiac conduction [inference]

cell-cell signaling involved in cardiac conduction

cell adhesion [inference]

cell-cell adhesion

homotypic cell-cell adhesion [inference]

cardiac muscle cell-cardiac muscle cell adhesion [inference]

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

heterotypic cell-cell adhesion [inference]

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization [inference]

intermediate filament bundle assembly

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization at cell tip

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization [inference]

intermediate filament bundle assembly

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

intermediate filament bundle assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

cell-cell junction organization [inference]

desmosome organization

desmosome assembly

cell-cell junction assembly [inference]

adherens junction organization [inference]

adherens junction maintenance

cell-cell junction maintenance [inference]

adherens junction maintenance

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

supramolecular fiber organization [inference]

intermediate filament organization [inference]

intermediate filament bundle assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization at cell tip

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization at cell tip

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

cell-cell signaling involved in cardiac conduction

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion

regulation of substrate adhesion-dependent cell spreading

positive regulation of cell adhesion

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of bicellular tight junction assembly

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

positive regulation of cellular process [inference]

positive regulation of cell adhesion

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell junction assembly [inference]

regulation of bicellular tight junction assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential

cardiac muscle cell action potential involved in contraction

ventricular cardiac muscle cell action potential

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

Displaying entries **21 - 25** of 25 in total

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GO Term	Evidence Code	PMID
cell junction	ISO
desmosome	ISS
desmosome	ISO
desmosome	IDA	22274697 38395410 9864371
cell tip	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction

cell-cell contact zone [inference]

intercalated disc

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

cell pole [inference]

cell tip

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
DNA binding	ISS
protein kinase C binding	ISO
protein kinase C binding	IEA
protein binding	IPI	17535849
intermediate filament binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase C binding

alpha-catenin binding

cell adhesion molecule binding [inference]

cadherin binding

intermediate filament binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

plakophilin-2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
alpha-catenin binding
cadherin binding
cell-cell junction assembly
cell-cell signaling involved in cardiac conduction
desmosome organization
intermediate filament binding
intermediate filament bundle assembly