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ATP binding cassette subfamily G member 8

Summary

Gene Symbol

Abcg8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

67470

PubChem

67470

Alliance of Genome Resources

MGI:1914720

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Glycoprotein
Lipid transport
Magnesium
Metal-binding
Proteomics identification
Reference proteome
Translocase
Transmembrane helix
Transport

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q7TSR6
E9Q0P2
Q9DBM0	Sterolin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
response to nutrient	IEA
response to xenobiotic stimulus	IEA
negative regulation of intestinal phytosterol absorption	ISO
negative regulation of intestinal phytosterol absorption	IEA
response to muscle activity	IEA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis

cholesterol homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to activity [inference]

response to muscle activity

response to chemical [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

transmembrane transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport

sterol transport

cholesterol transport [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	12208867
plasma membrane	IBA
apical plasma membrane	ISO
apical plasma membrane	IDA	12208867 16867993
apical plasma membrane	IMP	14504269

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

ATP-binding cassette (ABC) transporter complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12208867
ATP binding	ISO
ATP binding	IEA
ATP hydrolysis activity	ISO
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC transporter G family member

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ABC-type transporter activity
ATP binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter family G domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090019	sitosterolemia 1	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	31271	SGD:S000005435
Homo sapiens	64241	Xenbase:XB-GENE-981625	HUMAN62447
Xenopus tropicalis	67470	Xenbase:XB-GENE-981625
Saccharomyces cerevisiae S288C	114628	SGD:S000005435
Rattus norvegicus	155192	Xenbase:XB-GENE-981625	RATNO35102
Pan troglodytes	470363		PANTR27511
Canis lupus familiaris	474571		CANLF01797
Bos taurus	508829		BOVIN02313
Macaca mulatta	713676		MACMU07754
Xenopus tropicalis	854080	Xenbase:XB-GENE-981625

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements