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signal transducer and activator of transcription 5A
Summary
- Gene Symbol
-
- STAT5A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Activator
- Alternative splicing
- Cytoplasm
- DNA-binding
- Lactation
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- SH2 domain
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P42229 |
|
| K7EK35 |
|
| A0A384N5W4 |
|
| A8K6I5 |
|
| Q59GY7 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of endothelial cell proliferation | ||
| regulation of transcription by RNA polymerase II | ||
| defense response | ||
| receptor signaling pathway via JAK-STAT | ||
| receptor signaling pathway via JAK-STAT |
GO Hierarchy
- regulation of multicellular organism growth
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of cellular process [inference]
negative regulation of developmental process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
negative regulation of cell differentiation [inference]
regulation of cell development [inference]
regulation of hemopoiesis [inference]
negative regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell differentiation [inference]
negative regulation of cell differentiation [inference]
regulation of cell development [inference]
regulation of hemopoiesis [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
negative regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
negative regulation of cell activation [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| DNA-binding transcription factor activity, RNA polymerase II-specific | ||
| DNA-binding transcription factor activity, RNA polymerase II-specific | ||
| DNA-binding transcription factor activity | ||
| protein binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- signal transducer and transcription activator
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine-mediated signaling pathway |
| receptor signaling pathway via JAK-STAT |
| regulation of cell population proliferation |
| response to peptide hormone |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:234 | colon adenocarcinoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 103277170 | CARSF28633 | ||
| 103672571 | URSMA31285 | ||
| 103735895 | NANGA15453 | ||
| 105472122 | MACNE31152 | ||
| 105552959 | MANLE15353 | ||
| 105579667 | CERAT29688 | ||
| 105820251 | PROCO29409 | ||
| 106003240 | DIPOR04370 | ||
| 106826425 | EQUAS09424 | ||
| 107560759 | SINGR81135 |
