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syntaxin binding protein 2

Summary

Gene Symbol

STXBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6813

KEGG Gene ID

PubChem

6813

Alliance of Genome Resources

HGNC:11445

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Exocytosis
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q15833	Protein unc-18 homolog 2 Protein unc-18 homolog B
Q53GF4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
SNARE complex assembly	IDA
regulation of mast cell degranulation	ISS
neutrophil degranulation	IEP
cytotoxic T cell degranulation	IMP
regulated exocytosis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity

leukocyte degranulation [inference]

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity

vesicle-mediated transport

exocytosis [inference]

regulated exocytosis

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

SNARE complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

SNARE complex assembly

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

intracellular protein transport

establishment of localization [inference]

transport [inference]

protein transport

intracellular protein transport

vesicle-mediated transport

exocytosis [inference]

regulated exocytosis

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

intracellular transport [inference]

intracellular protein transport

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

establishment of protein localization [inference]

protein transport

intracellular protein transport

establishment of localization in cell [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

intracellular transport [inference]

intracellular protein transport

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

organelle localization [inference]

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of leukocyte mediated immunity [inference]

regulation of myeloid leukocyte mediated immunity [inference]

regulation of mast cell degranulation

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of cellular process [inference]

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
immunological synapse	IDA
extracellular region	TAS
cytosol	TAS
cytosol	IDA
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

zymogen granule membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

cytolytic granule membrane

secretory granule membrane [inference]

zymogen granule membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

primary lysosome [inference]

azurophil granule

cytolytic granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

primary lysosome [inference]

azurophil granule

cytolytic granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

presynapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
syntaxin-1 binding	IBA
syntaxin binding
syntaxin-3 binding	IBA
syntaxin-3 binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

SNARE binding [inference]

syntaxin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110925	familial hemophagocytic lymphohistiocytosis 5	Alliance of Genome Resources

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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