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syntaxin binding protein 2

Summary

Gene Symbol

STXBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6813

PubChem

6813

Alliance of Genome Resources

HGNC:11445

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Exocytosis
Protein transport
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53GF4	Protein unc-18 homolog 2 Protein unc-18 homolog B
Q15833	Protein unc-18 homolog 2 Protein unc-18 homolog B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
leukocyte mediated cytotoxicity	IMP	19884660
intracellular protein transport	IBA
vesicle docking involved in exocytosis	IBA
neurotransmitter secretion
vesicle-mediated transport

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity

leukocyte degranulation [inference]

neutrophil degranulation

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity

vesicle-mediated transport

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

neutrophil degranulation

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

exocytic process [inference]

vesicle docking involved in exocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

neutrophil degranulation

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

vesicle-mediated transport

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

neutrophil degranulation

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

neutrophil degranulation

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

neutrophil degranulation

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

neurotransmitter secretion

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

leukocyte degranulation [inference]

neutrophil degranulation

intracellular transport [inference]

intracellular protein transport

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

organelle localization [inference]

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis [inference]

presynaptic dense core vesicle exocytosis

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of leukocyte mediated immunity [inference]

regulation of myeloid leukocyte mediated immunity [inference]

regulation of mast cell degranulation

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of cellular process [inference]

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
cytosol	TAS
cytosol	IDA	18588921
plasma membrane	IDA	18588921
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

primary lysosome [inference]

azurophil granule

cytolytic granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

primary lysosome [inference]

azurophil granule

cytolytic granule

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

presynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19804848 19884660 33961781
syntaxin-1 binding	IBA
syntaxin-3 binding	IBA
syntaxin-3 binding	IPI	18588921

GO Hierarchy

molecular function

binding [inference]

protein binding

SNARE binding [inference]

syntaxin binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

syntaxin binding

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
syntaxin-1 binding
vesicle docking involved in exocytosis

Displaying **all 5** entries
InterPro
Sec1-like protein
Sec1-like superfamily
Sec1-like, domain 1
Sec1-like, domain 2
Sec1-like, domain 3a

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110925	familial hemophagocytic lymphohistiocytosis 5	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 68 in total

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Species	Gene ID	Orthologous MAtrix
Oreochromis niloticus	100695377	ORENI56204
Cavia porcellus	100720057	CAVPO15742
Cricetulus griseus	100768736	CRIGR17118
Sarcophilus harrisii	100924900	SARHA11583
Otolemur garnettii	100967176	OTOGA00430
Pan paniscus	100981706	PANPA19323
Papio anubis	101016911	PAPAN22191
Saimiri boliviensis boliviensis	101032686	SAIBB30874
Takifugu rubripes	101061780	TAKRU40797
Felis catus	101096543	FELCA05244