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potassium voltage-gated channel subfamily C member 4

Summary

Gene Symbol

Kcnc4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

684516

PubChem

684516

Alliance of Genome Resources

RGD:1589169

Annotation

Keyword

Glycoprotein
Metal-binding
Phosphoprotein
Potassium channel
Reference proteome
Transmembrane helix
Voltage-gated channel
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63734	Potassium voltage-gated channel subfamily C member 4 Raw3 Voltage-gated potassium channel subunit Kv3.4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
forebrain development	IEP	22473424
potassium ion transmembrane transport	IBA IEA
negative regulation of neuronal action potential	IMP	18048010
action potential	IBA
corpus callosum development	IEP	22473424

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

axon development

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

developmental process [inference]

anatomical structure development [inference]

nerve development [inference]

cranial nerve development [inference]

optic nerve development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion

negative regulation of biological process [inference]

negative regulation of action potential [inference]

negative regulation of neuronal action potential

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of neuronal action potential [inference]

negative regulation of neuronal action potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of neuronal action potential [inference]

negative regulation of neuronal action potential

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse [inference]

negative regulation of neuronal action potential

regulation of action potential [inference]

negative regulation of action potential [inference]

negative regulation of neuronal action potential

regulation of neuronal action potential [inference]

negative regulation of neuronal action potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of action potential [inference]

negative regulation of action potential [inference]

negative regulation of neuronal action potential

regulation of neuronal action potential [inference]

negative regulation of neuronal action potential

regulation of presynaptic membrane potential

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane	IBA IDA	14614103 15207333
glutamatergic synapse	IDA	14614103 15207333
axon	IDA	22473424
synaptic vesicle	IDA	15207333
dendrite	IDA	15207333

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

cell body membrane [inference]

neuronal cell body membrane

neuron projection terminus [inference]

axon terminus

calyx of Held

presynapse [inference]

axon terminus

calyx of Held

postsynapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
metal ion binding	IEA
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IMP NAS	12592408
voltage-gated potassium channel activity	IDA IEA ISO	1840526
protein binding	IPI	21943417
delayed rectifier potassium channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
neuronal cell body	PMID:15207333 PMID:22473424
dendrite	PMID:15207333
synaptic vesicle	PMID:15207333
postsynapse	PMID:15207333
cell surface	PMID:21943416
axon	PMID:22473424

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources