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GPI-anchored HDL-binding protein 1

Summary

Gene Symbol

Gpihbp1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

68453

PubChem

68453

Alliance of Genome Resources

MGI:1915703

Annotation

Keyword

Cell membrane
Disulfide bond
GPI-anchor
Hyperlipidemia
Lipid-binding
Reference proteome
Signal
Sulfation
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9D1N2	High density lipoprotein-binding protein 1
A0A087WNV7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein stabilization	IDA ISO	19542565
triglyceride catabolic process	ISO
triglyceride homeostasis	IBA IGI IMP ISO	17403372 19542565
positive regulation of chylomicron remnant clearance	IMP	17403372
response to heparin	ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

transcytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

establishment of protein localization [inference]

protein transport [inference]

multicellular organismal process [inference]

transcytosis

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to heparin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to heparin

response to oxygen-containing compound [inference]

response to heparin

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

establishment of protein localization [inference]

protein transport [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

lipid transport

sterol transport [inference]

cholesterol transport

protein transport [inference]

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

nitrogen compound transport [inference]

protein transport [inference]

establishment of protein localization [inference]

protein transport [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

establishment of protein localization [inference]

protein transport [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of chylomicron remodeling

positive regulation of multicellular organismal process [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of chylomicron remnant clearance

positive regulation of chylomicron remodeling

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of chylomicron remodeling

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of chylomicron remodeling

regulation of chylomicron remodeling [inference]

positive regulation of chylomicron remodeling

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of chylomicron remnant clearance

regulation of chylomicron remnant clearance [inference]

positive regulation of chylomicron remnant clearance

positive regulation of multicellular organismal process [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of chylomicron remnant clearance

positive regulation of chylomicron remodeling

regulation of chylomicron remodeling [inference]

positive regulation of chylomicron remodeling

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of triglyceride lipase activity [inference]

positive regulation of lipoprotein lipase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of triglyceride lipase activity [inference]

positive regulation of lipoprotein lipase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of triglyceride lipase activity [inference]

positive regulation of lipoprotein lipase activity

regulation of lipase activity [inference]

regulation of lipoprotein lipase activity [inference]

positive regulation of lipoprotein lipase activity

positive regulation of lipase activity [inference]

positive regulation of triglyceride lipase activity [inference]

positive regulation of lipoprotein lipase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IDA ISO	17403372 20620994
catalytic complex	ISO
apical plasma membrane	IDA	20620994
plasma membrane	IBA IDA	12496272
cell surface	IDA	12496272

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
lipoprotein lipase activator activity	ISO
protein transporter activity	IDA	20620994
lipase binding	IBA IPI ISO	17403372
chylomicron binding	IBA IMP ISO	17403372
lipoprotein particle binding	IMP ISO	17403372

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

lipase binding

lipid binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

lipase activator activity [inference]

lipoprotein lipase activator activity

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity [inference]

acetylcholine receptor inhibitor activity

neurotransmitter receptor regulator activity [inference]

acetylcholine receptor regulator activity [inference]

acetylcholine receptor inhibitor activity

molecular function activator activity [inference]

enzyme activator activity [inference]

lipase activator activity [inference]

lipoprotein lipase activator activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

acetylcholine receptor inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
chylomicron binding
lipase binding
triglyceride homeostasis

Displaying **all 2** entries
InterPro
Ly-6 antigen/uPA receptor-like
Snake toxin-like superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111420	familial GPIHBP1 deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 67 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Microtus oregoni	121461078	111838_0:0033ce
Dipodomys spectabilis	122125334	105255_0:003af9
Panthera leo	122210905		PANLE18555
Ursus americanus	123779297		URSAM31006
Marmota monax	124095758	9995_0:001509
Sciurus carolinensis	124991277	30640_0:000085
Perognathus longimembris pacificus	125360772	214514_0:002cbb
Myodes glareolus	125413270	447135_0:002dad
Microtus fortis	126503364	100897_0:001a1d
Acomys russatus	127201291	60746_0:002e01

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements